Search for dissertations about: "Cervical carcinoma"

Showing result 1 - 5 of 71 swedish dissertations containing the words Cervical carcinoma.

2. 1. Molecular Pathogenesis of Cervical Carcinoma : Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity

   Author : Xinrong Hu; Björn Hagmar; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical carcinoma; CIN; HPV; LOH; X-chromosome inactivation; clonality; molecular pathogenesis; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Abstract : A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and progresses through multiple steps from normal epithelium via CINS into invasive carcinomas. The aim of this study was to investigate the molecular mechanism of pathogenesis of cervical neoplasia. READ MORE

4. 2. Genetic Risk Factors for Cervical Carcinoma in situ

   Author : Anna Beskow; Peter L Stern; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Cervical carcinoma; human papillomavirus; viral load; long-term infection; HLA class II; p53; E6 variant; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Oncogenic human papillomaviruses (HPVs) are implicated in 99.7 % of cervical cancer cases but require the co-operation of other factors. To investigate potential genetic risk factors we have typed the HLA class II DRB1 and DQB1 loci in 478 women diagnosed with cervical carcinoma in situ and in 608 age-matched controls. READ MORE

5. 3. Human Papillomavirus Load and Cervical Carcinoma

   Author : Martin Moberg; Ulf Gyllensten; Björn Hagmar; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; cervical cancer; human papillomavirus; viral load; HLA class II; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Abstract : Human Papillomavirus (HPV) is a key factor in the development of cervical cancer. Out of the more than 100 known HPV types 13 are considered oncogenic. In addition to presence of the virus several other factors have been proposed to influence risk of cervical cancer. READ MORE

6. 4. Genetic and environmental risk factors of cervical carcinoma in Situ

   Author : Agnetha Josefsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Cervical carcinoma; Human papillomavirus; exonuclease assay; persistence; viral copy number; quantitation; p53; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Invasive cervical cancer is the third most common cancer form among women. In 1990 there were approximately 370,000 new cases diagnosed in the world. The risk of morbidity and mortality of cervical cancer among women is a problem, particularly in the developing countries. READ MORE

7. 5. Leucine-rich repeats and immunoglobulin-like domain (LRIG) proteins : possible prognostic markers in vulvar squamous cell carcinoma, endometrial carcinoma, and oropharymgeal squamous cell carcinoma

   Author : Husam Oda; David Lindquist; Eva Lundin; Ulrika Ottander; Kristina Stefansson; Kate Cuschieri; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vulvar squamous cell carcinoma; endometrial carcinoma; oropharyngeal squamous cell carcinoma; LRIG1-3; HPV; LMO7; HPV-driven; non-HPV-driven; prognosis; overall survival; disease-free survival; p53; Ki-67; CD8 TILs; CD44.; Pathology; patologi;

   Abstract : The human leucine-rich repeats and immunoglobulin-like domain (LRIG) gene family comprises three genes, LRIG1, LRIG2 and LRIG3, which encode the LRIG1, LRIG2 and LRIG3 proteins, respectively. Previous stidies have revealed the different prognostic roles of these proteins in different cancers, and it has been shown that LRIG1 functions as a tumour suppressor in certain cancers via its negative regulation of several receptor tyrosine kinases. READ MORE