Search for dissertations about: "Combination"

Showing result 1 - 5 of 6834 swedish dissertations containing the word Combination.

  2. 1. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Author : Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Abstract : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. READ MORE

  4. 2. Data-driven modeling of combination therapy in oncology

    Author : Tim Cardilin; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

    Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

  5. 3. Nonlinear Mixed Effects Modeling of Combination Therapies in Oncology

    Author : Marcus Baaz; Stiftelsen Fraunhofer-Chalmers Centrum för Industrimatematik (FCC); []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacol- ogy; Radiation Therapy; Oncology; Mathematical Modeling; Combination Therapy; Nonlinear Mixed Effects;

    Abstract : It has been shown that simultaneous administration of two or more anticancer agents can have a beneficial effect on cancer patients. This type of treatment is called combination therapy and is nowadays commonly used in the fight against cancer. READ MORE

  6. 4. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Author : Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. READ MORE

  7. 5. Modeling of combination therapy to support drug discovery in oncology

    Author : Tim Cardilin; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Pharmacokinetics Pharmacodynamics; Oncology; Nonlinear Mixed-Effects Models; Model-Based Drug Development; Combination Therapy;

    Abstract : Mathematical models based on ordinary differential equations, with impulses, are used to describe tumor growth after different treatment combinations, including chemicals as well as radiation. The models are calibrated, using a nonlinear mixed-effects framework, based on time series data of tumor volume from animal experiments. READ MORE