Search for dissertations about: "Complement C2 deficiency"
Showing result 1 - 5 of 7 swedish dissertations containing the words Complement C2 deficiency.
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1. Complement-dependent defence against bacterial infection. Studies in C2 deficiency
Abstract : The complement system is critically involved in defence against bacterial infection. C2 deficiency is, apart from mannan-binding lectin (MBL) deficiency, the most common homozygous complement deficiency among Caucasians. READ MORE
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2. Studies on hereditary C2 deficiency: Frequent occurrence of severe infections, atherosclerosis and rheumatological manifestations
Abstract : The complement system is a part of the innate immunity and is essential in the defence against microorganisms. Hereditary C2 deficiency (C2D) is one of the most common complement deficiency states with an estimated prevalence of 1:20,000 in persons of Western descent. READ MORE
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3. The Role of IgM and Complement in Antibody Responses
Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE
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4. Aspects on Immune Complex Handling and Complement Deficiency in Relation to Pathogenic Mechanisms in Systemic Lupus Erythematosus
Abstract : The autoimmune disease Systemic Lupus Erythematosus is associated with hereditary deficieny of early components from the classical pathway of complement activation, but not with deficiency of complement component C3 or of the alternative pathway components. The classical pathway is involved in elimination of pathological immune complexes from the circulation by transport via complement receptor type 1 (CR1). READ MORE
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5. Primary immunodeficiency in southern Sweden. Strategies for diagnosis and clinical management
Abstract : The overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identified cases. READ MORE