Search for dissertations about: "Cortical slice"

Found 4 swedish dissertations containing the words Cortical slice.

  2. 1. Role of Neuropeptides and Neurotrophic Factors in Seizure Modulation

    Author : Avtandil Nanobashvili; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; neurophysiology; brain slice; entorhinal cortex; hippocampus; galanin; glial cell line-derived neurotrophic factor; neuropeptide Y; epilepsy; kindling; Neurology; neurofysiologi; neuropsykologi; Neurologi;

    Abstract : The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2 (GFRa2), as well as neuropeptide Y (NPY) and galanin and their receptors in modulation of seizure activity. We demonstrate that mice lacking the GFRa2 gene (GFRa2-/-) exhibit suppressed seizure generalization in traditional and rapid kindling models. READ MORE

  4. 2. Automatic generation of patient specific models for hip surgery simulation

    Author : Johanna Pettersson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Simulation of surgical procedures in computer based simulator systems is a relatively new area of interest in the field of medical technology. Many different systems are under development, but it is still far until this technique becomes routine in a clinical environment. READ MORE

  5. 3. Adolescent Idiopathic Scoliosis. The Role of Low Dose Computed Tomography

    Author : Kasim Abul-Kasim; Malmö Diagnostisk radiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; low-dose spine CT; effective dose; screw misplacement; adolescent idiopathic scoliosis; outcome.; titanium screws; image quality; neurovascular complication; phantom;

    Abstract : Continuous implementation of new operative methods for correction and stabilization of spinal deformities in young patients with AIS demands a detailed morphological analysis of the vertebral column. CT spine according to protocols available in daily clinical practice means high radiation dose to these young individuals. READ MORE

  6. 4. Utility of combined treatment with antipsychotic and antidepressant drugs : scientific rationales and clinical implications

    Author : Carl Björkholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The atypical antipsychotic drug (APD) clozapine is the most efficacious APD in treatment-resistant schizophrenia including negative symptoms and cognitive impairment, and still lacks extrapyramidal side effects (EPS). Clozapine, which also possesses an antidepressant effect and can be used as monotherapy in bipolar disorder, has a broad receptor binding profile with higher affinity for the α2-adrenoceptor and several serotonergic receptors than D2 receptor, enhances dopamine output in the medial prefrontal cortex (mPFC) and facilitates glutamatergic NMDA receptor-mediated transmission in pyramidal cells in the same brain region. READ MORE