Search for dissertations about: "CpG Islands"

Showing result 1 - 5 of 19 swedish dissertations containing the words CpG Islands.

  2. 1. Genome-wide epigenetic profiling of B cell leukemia and lymphoma

    Author : Mohammad Hamdy Abdelrazak Morsy; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLL; PRC2; EZH2; Epigenetics; CpG islands; DNA methylation; ChIP-seq; RNA-seq;

    Abstract : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. READ MORE

  4. 2. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution

    Author : Jonas Berglund; Matthew Webster; Kerstin Lindblad-Toh; Leif Andersson; Nadia Singh; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; biased gene conversion; CpG island; copy number variation; substitutions; methylation; Bioinformatics; Bioinformatik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Molekylär genetik; Molecular Genetics;

    Abstract : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. READ MORE

  5. 3. Molecular characterization of the hepatitis C virus core protein

    Author : Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Abstract : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. READ MORE

  6. 4. Towards forecasting epigenetic repression

    Author : Moa J. Lundkvist; Yuri B. Schwartz; Ludvig Lizana; Peter V. Kharchenko; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; epigenetics; Polycomb; PRC1; PRC2; H3K27 methylation; Monte-Carlo simulation; chromatin structure; Drosophila; molekylär bioteknik inst f molekylärbiologi ; molecular biotechnology dept of molecular biology ;

    Abstract : Multicellular organisms form many different cell types from one genome, which requires differential gene activity. The Polycomb system upholds the correct gene expression programs by epigenetically silencing genes that encode critical transcription regulators. READ MORE

  7. 5. Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1

    Author : Maria Karlgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 is a superfamily of enzymes involved in the metabolism of endogenous and exogenous compounds. The P450 enzymes are expressed at high levels in the liver, but are also found in extrahepatic tissues and in transformed tissues. READ MORE