Search for dissertations about: "Cultured Cardiomyocytes"

Showing result 1 - 5 of 10 swedish dissertations containing the words Cultured Cardiomyocytes.

2. 1. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling

   Author : Urban Hellman; Anders Waldenström; Stellan Mörner; Anna Engström-Laurent; Lena Jonasson; Umeå universitet; []
   Keywords : hyaluronan; hyaluronan synthases; gene expression; extracellular matrix; cardiac hypertrophy; rat wistar; male ; cardiomyocytes; growth factors; fibroblasts; microvesicles; exosomes; MEDICINE; MEDICIN; Medicine; medicin;

   Abstract : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. READ MORE

4. 2. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

   Author : Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

   Abstract : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. READ MORE

5. 3. Pathophysiological importance of Beta1-Adrenergic receptor autoantibodies in the development of cardiomyopathy and heart failure. Clinically and experimentally

   Author : Lisa Buvall; Göteborgs universitet; []
   Keywords : Dilated Cardiomyopathy; Beta1 Adrenergic Receptor; Antibody; Cardiac; Function; Intravenous Immunoglobulin; Immunoadsorption; Cultured Cardiomyocytes; ; rat; mice; GRK2;

   Abstract : Idiopathic Dilated Cardiomyopathy (DCM) is a heart muscle disease of unknown originthat is characterized by ventricular dilation and the impaired contraction of the left orboth ventricles, resulting in progressive heart failure and sudden cardiac death. Antibodiesagainst different cardiac proteins have been found in DCM; they include antibodiesagainst the �1-adrenergic receptor (�1AR). READ MORE

6. 4. Role of calcium in developing cellular network : Ca2+ in human fetal neural stem cells and rat neonatal cardiomyocytes

   Author : Jeongsook Park; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis aimed to study Ca2+ homeostasis and its regulation in developing heart and brain cells. Cardiomyocytes rapidly developed a fast calcium machinery, (1) to regulate cytoskeletal protein interactions to the extracellular matrix of neighboring cells through gap junctions, and (2) to induce Ca2+-induced Ca2+ release (CICR) from sarcoplasmic reticulum (SR), (3) to generate rapid energy supply of ATP from mitochondria. READ MORE

7. 5. Size determination of hyaluronan and multivariate analysis of amyloid prone proteins

   Author : Linus Malm; Göran Larsson; Henrik Antti; Mary Cowman; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; Dynamic Light Scattering; GEMMA; Amyloid Aggregation; Multivariate Analysis; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry; fysikalisk kemi; Physical Chemistry;

   Abstract : Background.The extracellular matrix surrounds all cells within our bodies. The glycosaminoglycan hyaluronan is a major component in the extracellular matrix. Despite its structural simplicity it has been shown to be involved in several important functions. READ MORE