Search for dissertations about: "Cys"

Showing result 1 - 5 of 60 swedish dissertations containing the word Cys.

  2. 1. Modulating Enzyme Functions by Semi-Rational Redesign and Chemical Modifications : A Study on Mu-class Glutathione Transferases

    Author : Malena A Norrgård; Bengt Mannervik; Birgitta Tomkinson; Timothy Mantle; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein redesign; semi-rational redesign; saturation mutagenesis; iterative saturation mutagenesis; chemical modification; Cys; Cys-X scanning; enzyme evolution; promiscuous; substrate selectivity; enantioselectivity; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Today, enzymes are extensively used for many industrial applications, this includes bulk and fine-chemical synthesis, pharmaceuticals and consumer products. Though Nature has perfected enzymes for many millions of years, they seldom reach industrial performance targets. READ MORE

  4. 2. Elucidating the Gating Mechanism of Cys-Loop Receptors

    Author : Özge Yoluk; Erik Lindahl; Philip Biggin; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channel; gating; simulation; molecular dynamics; receptor; cys-loop; modelling; Teoretisk kemi och biologi; Theoretical Chemistry and Biology; Biological Physics; Biologisk fysik;

    Abstract : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. READ MORE

  5. 3. Regulation of human thioredoxin and glutaredoxin systems by oxidation and S-nitrosylation

    Author : Seyed Isaac Hashemy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The homeostasis of intracellular redox status has a crucial role in the cell survival and different processes such as DNA synthesis, gene expression, enzymatic activity, etc. This homeostasis is achieved via an intense balance between pro-oxidants and anti-oxidants. READ MORE

  6. 4. Sulfur amino acids and their metabolites in patients with renal failure : relation to nutritional status and cardiovascular disease

    Author : Mohamed Elsaeid M Suliman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cardiovascular disease; chronic renal failure; cysteine; diabetes mellitus; glutathione; homocysteine; malnutrition; serum albumin; sulfur amino acids; taurine;

    Abstract : Patients with chronic renal failure (CRF) have a high prevalence of cardiovascular disease (CVD), malnutrition and diabetes mellitus (DM) and exhibit several abnormalities in amino acid metabolism. The aims of this thesis were to assess alterations in sulfur amino acids and related sulfur compounds in relation to nutritional status, CVD and DM in CRF patients. READ MORE

  7. 5. Synthesis, Characterization and Application of 68Ga-labelled Peptides and Oligonucleotides

    Author : Irina Velikyan; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi;

    Abstract : The positron emitting 68Ga radionuclide (T1/2 = 68 min) has the potential of practical interest for clinical PET. The metallic cation, 68Ga3+, is suitable for complexation reactions with chelators either naked or conjugated with macromolecules such as peptides and oligonucleotides. READ MORE