Search for dissertations about: "D-optimal"
Showing result 1 - 5 of 13 swedish dissertations containing the word D-optimal.
-
1. Locally D-optimal Designs for Bivariate Logistic Regression
Abstract : .... READ MORE
-
2. Experimental Designs at the Crossroads of Drug Discovery
Abstract : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. READ MORE
-
3. Computational Diffusion MRI: Optimal Gradient Encoding Schemes
Abstract : Diffusion-weighted magnetic resonance imaging (dMRI) is a non-invasivestructural imaging technique that provides information about tissue microstructures.Quantitative measures derived from dMRI reflect pathologicaland developmental changes in living tissues such as human brain. READ MORE
-
4. Optimal adaptive designs and adaptive randomization techniques for clinical trials
Abstract : In this Ph.D. thesis, we investigate how to optimize the design of clinical trials by constructing optimal adaptive designs, and how to implement the design by adaptive randomization. READ MORE
-
5. Optimal Design and Inference for Correlated Bernoulli Variables using a Simplified Cox Model
Abstract : This thesis proposes a simplification of the model for dependent Bernoulli variables presented in Cox and Snell (1989). The simplified model, referred to as the simplified Cox model, is developed for identically distributed and dependent Bernoulli variables. READ MORE