Search for dissertations about: "DAMGO"
Showing result 1 - 5 of 7 swedish dissertations containing the word DAMGO.
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1. Quantitative Aspects of Nanodelivery Across the Blood-Brain Barrier : Exemplified with the Opioid Peptide DAMGO
Abstract : The use of nanocarriers is an intriguing approach in the development of efficacious treatment for brain disorders. The aim of the conducted research was to evaluate and quantify the impact of a liposomal nanocarrier formulation on the brain drug delivery. READ MORE
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2. Long-term Effects of Opioids in the Treatment of Chronic Pain : Investigation of Problems and Hazards on Clinical, Biochemical, Cellular and Genetic Levels
Abstract : After two decades of liberal prescribing of opioids, there has been an increasing recognition of problems connected to the prolonged use of opioids for chronic pain. The aim of my thesis was to explore some consequences of long-term opioid treatment for chronic pain such as problematic opioid use, endocrine disorders, tolerance and genetic variations in pain and opioid response. READ MORE
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3. Characterization of Substance P (SP) Aminoterminal SP (1-7) Binding in Brain Regions and Spinal Cord of the Male Rat : Studies on the Interaction with Opioid Related Pathways
Abstract : Binding sites for substance P(1-7), SP(1-7) have been identified and characterized for the first time in crude membrane fraction from rat CNS using tritiated ([3H]) SP(1-7) as tracer. These putative receptors were investigated in relation to their affinity for tachykinins, opioid peptides and sigma receptor ligands. READ MORE
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4. In vitro and postmortem studies of the brain opioid system : association to opiate dependence
Abstract : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. READ MORE
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5. Opioid-induced cholecystokinin release in the CNS-neurochemical mechanisms and effects of sciatic nerve lesion
Abstract : Cholecystokinin (CCK) and opioid peptides have a similar distribution in the nervous system and CCK has been demonstrated to counteract opioid-induced analgesia at spinal and supraspinal level. An increased spinal release of CCK has been suggested to be a mechanism for the relative resistance to opioid analgesic drug in certain pain conditions following nerve lesions (i. READ MORE