Search for dissertations about: "DNA aberration"

Showing result 1 - 5 of 27 swedish dissertations containing the words DNA aberration.

  2. 1. Genetic Analyses of Tumor Progression in Colorectal Cancer

    Author : Kristina Lagerstedt; Göteborgs universitet; []
    Keywords : colorectal cancer; tumor progression; microarray; DNA aberration; gene expression; microRNA; structural variation;

    Abstract : Colorectal tumors are responsible for more than 600 000 deaths per year worldwide and thereby constitute the second most common cause of cancer related mortality. Early detection is related to improved prognosis and identification of genetic biomarkers would meliorate available diagnostic tools. READ MORE

  4. 2. Studies on genetic aberrations as possible predictors of the outcome of assisted reproduction

    Author : Mona Bungum; Malmö Reproduktionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; assisted reproduction; IUI; Sperm chromatin; ICSI; intra-individual variation; fertilisation failure genetic aberration; Protein C inhibitor gene; sperm DNA damage SCSA; IVF;

    Abstract : Traditionally, diagnosis of male infertility has relied upon microscopic assessment of semen. The normality criteria set by the World Health Organization (WHO) in regard to sperm concentration, motility and morphology are, however, poor predictors of fertility. READ MORE

  5. 3. Mitotic aberrations in mammalian cells

    Author : Anna Renglin Lindh; Thomas Helleday; Micheline Kirsch-Volders; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aneuploidy; mitotic aberrations; chemical effects; human cancer; DNA repair; Genetics; Genetik;

    Abstract : Almost all cancer cells are aneuploid showing the wrong chromosome number and often with structural aberrations. The degree of aneuploidy correlates with an increase of the severity of the disease and tumour cells with chromosomal instability are more prone to acquire resistance to chemotherapy than other cells. READ MORE

  6. 4. Exposure, telomere length, and cancer risk

    Author : Huiqi Li; Avdelningen för arbets- och miljömedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; exposure; telomere; methylation; chromosomal aberration; cancer risk; rubber fumes; arsenic; welding fumes; diesel exhaust; particulate matter;

    Abstract : Telomeres are tandem repeats of TTAGGG at the end of eukaryotic chromosomes. Telomeres play a key role in chromosome stability and regulation of the cellular lifespan. Telomeres are shortened during cell division, and probably, by not yet well characterised factors in the environment. READ MORE

  7. 5. Genetic and Epigenetic Profiling of Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia

    Author : Anna Margrét Halldórsdóttir; Richard Rosenquist; Reiner Siebert; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mantle cell lymphoma; chronic lymphocytic leukemia; copy number aberration; proliferation signature; TP53; SNP array; methylation array; Haematology; Hematologi; Clinical genetics; Klinisk genetik; Molecular biology; Molekylärbiologi; Tumour biology; Tumörbiologi; Medical Genetics; Medicinsk genetik; Oncology; Onkologi; Molekylär medicin; Molecular Medicine; Pathology; Patologi;

    Abstract : Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) both belong to the group of mature B-cell malignancies. However, MCL is typically clinically aggressive while the clinical course of CLL varies. READ MORE