Search for dissertations about: "DNA damage oxidative stress"

Showing result 1 - 5 of 54 swedish dissertations containing the words DNA damage oxidative stress.

2. 1. Oxidative damage and the DNA glycosylase MutYH

   Author : Kristina Jansson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Oxidative damage; 8-oxo-7; 8-dihydro-2′-deoxyguanosine; Base excision repair; DNA glycosylase; Mismatch repair; DNA damage checkpoint; 9-1-1 complex; Glutathione-S-transferases; Colon cancer.;

   Abstract : The DNA glycosylase MutYH is highly conserved throughout evolution, and homologs are found in most eukaryotes and prokaryotes examined. MutYH functions as a base excision repair DNA glycosylase that excises adenines misincorporated opposite 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), one of the most stable products of oxidative DNA damage. READ MORE

4. 2. The oxidative stress response of Francisella tularensis

   Author : Marie Honn; Anders Sjöstedt; Helena Lindgren; Andres Melendez; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; FupA; MglA; OxyR; ROS; oxidative stress; molekylärbiologi; Molecular Biology;

   Abstract : Francisella tularensis is capable of infecting numerous cell types, including professional phagocytes. Upon phagocytosis, F. tularensis resides within the phagosome before escaping into the cytosol to replicate. Phagocytes constitute a hostile environment rich in ROS, which are employed as a means of killing pathogens. READ MORE

5. 3. Effect of Dietary Antioxidants on Oxidative Stress, Inflammation and Metabolic Factors : Studies in Subjects with Overweight and with Type 2 Diabetes

   Author : Elisabet Rytter; Samar Basu; Bengt Vessby; Anders Sjödin; Helmut Sies; Uppsala universitet; []
   Keywords : Antioxidants; supplementation; fruit and vegetables; oxidative stress; isoprostanes; lipid peroxidation; oxidative damage to DNA; glycaemic control; inflammation; overweight; type 2 diabetes; MEDICINE; MEDICIN; Nutrition; Nutrition;

   Abstract : Observational studies have indicated that fruit and vegetables, and dietary antioxidants may play an important role in reducing the risk of chronic diseases, potentially by affecting pathogenic mechanisms such as oxidative stress and inflammation. Clinical trials investigating the effects of supplementation with single or a few antioxidants in high doses have, however, shown inconsistent results and thus have not been able to support the observational findings. READ MORE

6. 4. The consequences of DNA lesions for mitochondrial DNA maintenance

   Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

   Abstract : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE

7. 5. Role of oxidative stress response in radiosensitivity

   Author : Ali Pour Khavari; Siamak Haghdoost; Bo Stenerlöw; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Oxidative stress; radiosensitivity; 8-oxo-dG; DNA-repair; NRF2; glioblastoma; radiotherapy; molekylär biovetenskap; Molecular Bioscience;

   Abstract : The quality of the ionizing radiation (IR) can be described in terms of its nature, photons or particles, and their corresponding energies. The energy is classified in terms of High or Low linear energy transfer that will produce a different distribution of DNA damage and other molecules in the cell either by direct action or indirect action. READ MORE