Search for dissertations about: "DNAJ"
Showing result 1 - 5 of 9 swedish dissertations containing the word DNAJ.
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1. The Molecular Chaperone DNAJB6 - A Suppressor of Disease Related Amyloid Fibril Formation
Abstract : Several neurodegenerative diseases are caused by peptides or proteins forming amyloid fibrils such as the Aβ peptide involved in Alzheimer’s disease and the huntingtin exon-1 with a prolonged polyglutamine (polyQ) stretch involved in Huntington’s disease. The ability to form amyloid fibrils is an intrinsic feature in all proteins. READ MORE
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2. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization
Abstract : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. READ MORE
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3. Meticulous control of the T3SS of Yersinia is essential for full virulence
Abstract : The type III secretion system (T3SS) of pathogenic Yersinia pseudotuberculosis is involved in virulence. The syringe-like secretion system spans both bacterial membranes and is responsible for the ability of Yersinia to transfer toxic proteins (Yop proteins) into the eukaryotic target cell. READ MORE
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4. Activity of tumor-antigens in polyomavirus replication
Abstract : Polyomavirus replication needs an active cell environment, and the viral DNA replication is cell cycle regulated. Tumor antigens (T-antigens) of mouse polyomavirus, especially large T-antigen, are necessary for the replication. READ MORE
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5. Characterisation of the novel endoplasmic reticulum chaperone ERDJ5
Abstract : Communication between cells depends to a large extent on interactions between secreted proteins and membrane receptors. Therefore their production and release must be strictly regulated. Proteins that are destined for the extracellular space assemble and fold in the endoplasmic reticulum (ER). READ MORE