Search for dissertations about: "David Drew"
Showing result 1 - 5 of 12 swedish dissertations containing the words David Drew.
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1. GFP as a tool to monitor membrane protein topology and overexpression in Escherichia coli
Abstract : Membrane proteins are essential for life, and roughly one-quarter of all open reading frames in sequenced genomes code for membrane proteins. Unfortunately, our understanding of membrane proteins lags behind that of soluble proteins, and is best reflected by the fact that only 0. READ MORE
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2. Determining Ligand- and Lipid- Interactions of SLC Transporters
Abstract : Solute carrier transporters (SLCs) mediate the inter- and intra- cellular trafficking of a plethora of substrates and are essential to cell homeostasis. Despite their importance to human physiology and their potential as therapeutic targets, many SLCs are considered orphans as the physiological substrate has not been experimentally determined. READ MORE
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3. Nanoscopic adventures : unraveling macromolecular complexes in infectious diseases via integrative structural biology
Abstract : This thesis focuses on understanding the underlying molecular mechanisms of infectious diseases, which claim nearly 9 million lives annually. The research centers on critical analysis of pathogen mechanisms and drug resistance. I have mainly focused on two clades of pathogens: Enterococcus faecalis and microsporidia. E. READ MORE
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4. Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system
Abstract : Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. READ MORE
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5. The molecular basis for substrate recognition and gating in sugar transporters
Abstract : Sugar is a vital sustenance for most forms of life. For a cell to take up sugar, specialized transport proteins embedded into the membrane bilayer known as sugar porters, are required. READ MORE