Search for dissertations about: "Dendritic excitability"

Showing result 1 - 5 of 7 swedish dissertations containing the words Dendritic excitability.

  2. 1. Mechanisms of excitability in the central and peripheral nervous systems : Implications for epilepsy and chronic pain

    Author : Jenny Tigerholm; Erik Fransén; Dieter Jaeger; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dendritic excitability; synchronized synaptic input; multicompartment model; epilepsy; axonal excitability; silent C–fibres; Hodgkin–Huxley dynamics; conduction velocity; KA;

    Abstract : The work in this thesis concerns mechanisms of excitability of neurons. Specifically, it deals with how neurons respond to input, and how their response is controlled by ion channels and other active components of the neuron. READ MORE

  4. 2. A-type Potassium Channels in Dendritic Integration : Role in Epileptogenesis

    Author : Jenny Tigerholm; Erik Fransén; Fredrik Elinder; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; epileptogenesis; fast ripples; synchronicity; dendritic potentials; transient A–type potassium current; KV 4.2; Computer and systems science; Data- och systemvetenskap;

    Abstract : During cognitive tasks, synchronicity of neural activity varies and is correlated with performance. However, there may be an upper limit to normal synchronised activity – specifically, epileptogenic activity is characterized byexcess spiking at high synchronicity. READ MORE

  5. 3. Dendritic and axonal ion channels supporting neuronal integration : From pyramidal neurons to peripheral nociceptors

    Author : Marcus Petersson; Erik Fransén; Theodore Cummins; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ion channels; computational modeling; simulations; dendrites; axons; TRP; hippocampus; C-fiber nociceptors; pain;

    Abstract : The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. READ MORE

  6. 4. K+ channels and the regulation of synaptic transmission

    Author : Evanthia Nanou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Neuronal excitability is highly regulated by K+ channels that are activated by a voltage change across the plasma membrane or by a rise in intracellular Na+ or Ca2+ concentration. The main focus of this thesis has been to characterize the Na+-activated K+ (KNa) and the Ca2+-activated K+ (KCa) channels and to determine their role in regulating synaptic transmission in the lamprey spinal cord. READ MORE

  7. 5. Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy

    Author : Natalia Avaliani; Epilepsicentrum; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chemogenetics; iPS; iN; electrophysiology; gene and cell therapy; Epilepsy;

    Abstract : The complexity of the central nervous system and existence of the blood-brain barrier often causes difficulties for traditional pharmacological treatments of neurological diseases. This thesis explores the feasibility and potential for novel gene and cell therapy approaches, which hold better promise for neurological disorders, while particularly targeting epilepsy. READ MORE