Search for dissertations about: "Deoxycytidine"

Showing result 1 - 5 of 27 swedish dissertations containing the word Deoxycytidine.

  2. 1. Pharmacology and resistance mechanisms of nucleoside analogues and topoisomerase II interactive agents : studies on human leukemia cells with a focus on cross-resistance

    Author : Kourosh Lotfi; Rolf Larsson; Linköpings universitet; []
    Keywords : Nucleoside analogue; cross-resistance; multidrug resistance; deoxycytidine kinase; leukemia; anthracyclines; P-glycoprotein; MEDICINE; MEDICIN;

    Abstract : The purpose of this thesis was to elucidate mechanisms of action and resistance of clinically relevant nucleoside analogues and topoisomerase interactive agents in human leukemia cell lines and leukernia cells isolated from peripheral blood of leukemia patients. Interactions and cross-resistance patterns of these different cytotoxic drug families were also studied since these drugs are usually administrated in combination in the clinic. READ MORE

  4. 2. Retroviral and related nucleic acid processing enzymes expression and detection : Applications on clinical studies of HIV and HERVs

    Author : Raymond Awad; Amnon Hizi; Uppsala universitet; []
    Keywords : Medical sciences; Reverse transcriptase; endogenous retrovirus; deoxycytidine kinase; HIV; HERVS; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medical Virology; medicinsk virologi;

    Abstract : Reverse transcriptase (RT), the expression and detection of the enzyme marking the family Retroviridae, has been studied. A new RT activity assay adapted to 96-well microtitre plates is described. It uses a non- radioactive bromodeoxyuridine triphosphate (BrdUTP) substrate in a solid phase format. The assay was highly sensitive. READ MORE

  5. 3. A Molecular Dissection of Mantle Cell Lymphoma - From gene expression analysis to functional evaluation of selected targets

    Author : Venera Kuci; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; side population; deoxycytidine kinase; resistance; SOX11; mantle cell lymphoma;

    Abstract : Mantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. READ MORE

  6. 4. Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments

    Author : Chaoyong Zhu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; deoxyguanosine kinase; deoxycytidine kinase; nucleoside analogs; mitochondria; phosphorylation;

    Abstract : Nucleoside analogs have been developed as anticancer and antiviral agents. The main mechanism of action of nucleoside analogs is the incorporation of the corresponding analog triphosphate into DNA where it interferes with DNA replication. READ MORE

  7. 5. The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

    Author : Zeeshan Mutahir; Molekylär cellbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc. READ MORE