Search for dissertations about: "Differentiated thyroid cancer"

Showing result 1 - 5 of 11 swedish dissertations containing the words Differentiated thyroid cancer.

  2. 1. Tumour stromal and demographical factors affecting the metastatic aggressiveness of small differentiated papillary thyroid cancers in Sweden

    Author : Haytham Bayadsi; Joakim Hennings; Malin Sund; Robert Bränström; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Papillary thyroid cancer; Tumour stroma; Geographic information system; Register; Surgery; kirurgi;

    Abstract : Background: The incidence of papillary thyroid cancer (PTC) has been increasing over the recent decades, especially that of small papillary thyroid cancers (sPTCs) (≤ 20mm in size). sPTCs are generally classified as low risk cancers with a very favourable diagnosis, yet some of these cancers still cause locoregional and distant metastasis, recurrence and even death. READ MORE

  4. 2. Reversal of thyroid dedifferentiation and an invasive phenotype by small molecule kinase inhibitors: an experimental study on normal and malignant cells

    Author : Camilla Ingeson-Carlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thyroid; cancer; NIS; MAPK; PI3K; BRAFV600E; migration; 3D culture;

    Abstract : Refractoriness to I-131 in dedifferentiated thyroid cancer is a great concern that restricts radioiodine therapy. There is also a lack of knowledge in understanding the mechanisms leading to repressed sodium iodide symporter (NIS) expression and impaired iodide uptake in tumor cells. READ MORE

  5. 3. DNA damage affecting thyroidal iodide transport: an explanation to thyroid stunning

    Author : Madeleine Nordén; Göteborgs universitet; []
    Keywords : thyroid; radioiodide; thyroid stunning; NIS; cell cycle; genotoxic stress; DNA damage; H2AX; ATM;

    Abstract : 131I is widely used clinically in the treatment of Graves´ disease and differentiated thyroid cancer. However, cellular and molecular effects of 131I irradiation in relation to absorbed dose are poorly documented. READ MORE

  6. 4. Incidence and prognosis of differentiated thyroid cancer in Sweden

    Author : Catharina Ihre Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Differentiated thyroid cancer; papillary; follicular; nested case-control study; population-based; risk factors; prognosis; survival; TNM.;

    Abstract : Non-medullary differentiated thyroid cancer (DTC) is a rare disorder but, nevertheless, among the most common cancers in individuals below 40 years of age. DTC consists of papillary (PTC) and follicular (FTC) thyroid cancer. The prognosis is excellent with an overall 10-year survival of 90 %. READ MORE

  7. 5. Avidity-guided radionuclide therapy for thyroid cancer

    Author : Joachim Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The treatment of differentiated thyroid cancer has three main modalities: surgery, hormone suppression and radioiodine therapy. Effective radioiodine therapy requires cancer cells to be iodine avid, i.e. exhibit relatively functional iodine transport and retention. READ MORE