Search for dissertations about: "Disease Susceptibility"

Showing result 1 - 5 of 561 swedish dissertations containing the words Disease Susceptibility.

  2. 1. Susceptibility genes in conformational diseases

    Author : Malin von Otter; Göteborgs universitet; []
    Keywords : Conformational disease; Alzheimer’s disease; Parkinson’s disease; Cataract Protein aggregation; Cellular transport; Oxidative stress; Susceptibility; genes; SNP; Haplotype;

    Abstract : Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent ... READ MORE

  4. 2. Susceptibility to chronic liver disease

    Author : Maria Antonella Burza; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic liver disease; susceptibility; human genetics; NAFLD; ALD; PNPLA3;

    Abstract : The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. READ MORE

  5. 3. The Complex Genetics behind Neurodegeneration and Susceptibility to Parkinson’s disease

    Author : Michael Jewett; Translationell Neurogenetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson’s Disease; α-synuclein; Dopaminergic Neurons; Susceptibility; GSTA4; Vra1; rAAV; 6-OHDA; En1; Linkage analysis; Congenic strains; Axonal swellings; QTL; Risk factors; Neuroprotection; Astrocytes;

    Abstract : Parkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest. READ MORE

  6. 4. Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course

    Author : Alf Kastbom; Thomas Skogh; Peter Söderkvist; Alex Karlsson-Parra; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; autoantibodies; single-nucleotide polymorphisms; disease course; Rheumatology; Reumatologi;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial joints. Although its causes remain largely unknown, a substantial genetic contribution is known to exist. READ MORE

  7. 5. Clinical and genetical aspects of Celiac Disease

    Author : Audur Gudjonsdottir; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; sib-pair; screening; genome-wide scan; linkage analysis; heritability; genotypes; DQ2-negative; phenotypes; autoimmune disease;

    Abstract : Celiac disease (CD), or gluten-sensitive enteropathy, is one of the most common chronic diseases in childhood but is diagnosed in all ages. CD is a genetically driven immunological intolerance to dietary gluten. Th e treatment is a gluten-free diet. READ MORE