Search for dissertations about: "Dosing strategy"

Showing result 1 - 5 of 18 swedish dissertations containing the words Dosing strategy.

2. 1. Estimation of Dosing Strategies for Individualisation

   Author : Siv Jönsson; Mats O. Karlsson; Leon Aarons; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Dosing strategy; Individualisation; Pharmacokinetic; Pharmacodynamic; Modeling; NONMEM; Decision making; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci;

   Abstract : To increase the proportion of patients with successful drug treatment, dose individualisation on the basis of one or several patient characteristics, a priori individualisation, and/or on the basis of feedback observations from the patient following an initial dose, a posteriori individualisation, is an option. Efficient tools in optimising individualised dosing strategies are population models describing pharmacokinetics (PK) and the relation between pharmacokinetics and pharmacodynamics (PK/PD). READ MORE

4. 2. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

   Author : Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; Uppsala universitet; []
   Keywords : Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

   Abstract : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). READ MORE

5. 3. Studies of a Heavy-Duty Diesel Aftertreatment System Based on the NOX Storage and Reduction Technology

   Author : Klaus Papadakis; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; fuel penalty; injection parameters; DoE; design of experiments; exhaust; diesel engine; NO oxidation; simulation; modelling; oxidation catalyst; NOX trap; NOX storage and reduction; NSR; Kemiteknik och kemisk teknologi; Chemical technology and engineering; dosing strategy; system optimisation;

   Abstract : The legislative limits for NOX emissions in the exhaust gas from heavy-duty diesel engines will be decreased in the European Union from today 3.5 g/kWh (Euro IV) to 2.0 g/kWh in 2008 (Euro V). In the USA and Japan a similar trend can be seen. READ MORE

6. 4. Catalytic Reduction of NOx on Heavy-Duty Trucks

   Author : Christian Künkel; Avdelningen för kemiteknik; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kemiteknik och kemisk teknologi; Chemical technology and engineering; real time; strategy; model; catalysis; exhaust gas; diesel; automotive; deNOx; NOx reduction; NOx storage; HC-SCR; Carbochemistry; petrochemistry; fuels and explosives technology; Petrokemi; bränslen; sprängämnen;

   Abstract : The objective of the work described in this thesis is to identify the principles and parts of an aftertreatment system for the catalytic NOx reduction for heavy-duty diesel vehicles, and to demonstrate such a system in full-scale. The reducing agent is diesel fuel. READ MORE

7. 5. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

   Author : Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. READ MORE