Search for dissertations about: "Drug Hypersensitivity"

Showing result 1 - 5 of 16 swedish dissertations containing the words Drug Hypersensitivity.

2. 1. Submicron Calcium Phosphate Spheres for Biomedical Applications : Synthesis and Use

   Author : Tao Qin; Håkan Engqvist; Fredrik Nikolajeff; Jie Huang; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; calcium phosphate; spheres; dentinal hypersensitivity; drug release; tooth bleaching;

   Abstract : Calcium phosphate spheres as biomaterials have been attracting attention in recent years. Calcium phosphate occurs naturally in bone, and a hollow structure could be advantageous for drug loading and release. READ MORE

4. 2. On the hypersensitivity syndrome induced by the selective serotonin reuptake inhibiting antidepressant Zimeldine : A clinical and experimental study

   Author : Bengt-O Bengtsson; Linköpings universitet; []
   Keywords : Zimeldine; Norzimeldine; Hypersensitivity syndrome; Serotonin reuptake inhibition; Genetic disposition; Lymphocyte transformation test; Experimental allergic neuritis; Immunopharmacology; MEDICINE; MEDICIN;

   Abstract : Zimeldine, the first selective neuronal serotonin (5-H1) reuptake inhibitor to be registered as an antidepressant was withdrawn from common use due to an acute flu-like adverse syndrome comprising fever, myalgia and/or arthralgia and signs of disturbed liver function. A few of these patients also developed a peripheral neuropathy, in the most serious form a Guillain-Barré syndrome (GBS). READ MORE

5. 3. Assessing the importance of rare genetic variants for drug response

   Author : Yitian Zhou; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Inter-individual variability in drug response is commonly observed in pharmacological treatment, resulting in 40-70% of patients suffering from low drug efficacy or adverse drug reactions. These negative therapeutic effects significantly contribute to patient morbidity and mortality and constitute an important reason of post-market drug withdrawal. READ MORE

6. 4. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

   Author : Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

   Abstract : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. READ MORE

7. 5. Drug-enhanced spinal cord stimulation for neuropathic pain : studies on neurochemical mechanisms and clinical applications

   Author : Gastón Schechtmann; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Acetylcholine; baclofen; cholinergic analgesia; clonidine; gabapentin; neuropathic pain; nerve injury; pregabalin; spinal cord stimulation; intrathecal drug;

   Abstract : Spinal cord stimulation (SCS) is an effective surgical treatment for neuropathic pain refractory to pharmacological therapy. For many patients suffering from this type of chronic pain, SCS is in fact the ultimate treatment option. READ MORE