Search for dissertations about: "EBV"

Showing result 1 - 5 of 151 swedish dissertations containing the word EBV.

  2. 1. Characterization of Epstein-Barr virus non-coding RNAs in infected cells

    Author : Guojiang Xie; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EBV; EBV-associated malignancies; viral gene expression pattern; RPMS1; EBERs; single-cell sequencing; ChIRP; immune evasion; protein synthesis;

    Abstract : Epstein-Barr virus (EBV) causes multiple types of lymphoid and epithelial malignancies. Unraveling the viral gene expression patterns in tumors and identifying interaction partners between EBV and host elements is crucial for understanding EBV tumorigenesis. READ MORE

  4. 2. Opportunistic viral infection after paediatric transplantation

    Author : Carola Kullberg-Lindh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Paediatric liver transplantation; paediatric stem cell transplantation; immunosuppression; opportunistic; CMV; EBV; AdV; HHV-6; real-time PCR; monitoring; specimen; post transplant lymphoproliferative disease;

    Abstract : Background: Opportunistic viral infections can cause considerable morbidity and mortality in organ and stem cell transplanted (SCT) patients, mainly due to iatrogenic T cell dysfunction. Whereas in SCT patients, in general the immunosuppressive treatment can be discontinued after 6-12 months, for the majority of organ transplanted patients, the need for treatment is life-long. READ MORE

  5. 3. Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis

    Author : Siamak Akbari Kamranvar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : EBV;

    Abstract : EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of genomic instability, as defined by the accumulation of non-clonal genetic aberrations, could play a role in EBV oncogenesis and identify the viral protein(s) responsible for this phenotype. READ MORE

  6. 4. Regulation and expression of Epstein-Barr virus nuclear antigen 1 in transplant patients and cell culture

    Author : Malin Berggren; Göteborgs universitet; []
    Keywords : EBV;

    Abstract : Epstein-Barr virus (EBV) is a human herpes virus that infects over 90% of the world population. Once infection has occurred, the virus persists for life in its host, mainly in an asymptomatic, latent stage with only a few active viral genes. READ MORE

  7. 5. Activation, adhesion and motility of B lymphocytes in health and disease

    Author : Natalija Gerasimcik; Eva Severinson; Victor Tybulewicz; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; B cells; activation; motility; IL-4; EBV; Dock10; Cdc42; Rac1 and Rac2; immunologi; Immunology;

    Abstract : B cells can be activated by T cell-dependent stimuli, such as CD40 ligation and cytokines, which induce extensive proliferation, class switch recombination and somatic hypermutation.Epstein-Barr virus (EBV) can also induce B cell activation by mimicking T cell help through its main oncoprotein, latent membrane protein 1 (LMP-1). READ MORE