Search for dissertations about: "ER serotonin"

Found 4 swedish dissertations containing the words ER serotonin.

2. 1. Tryptophan-related Neurotransmission in the Brain: Disturbances Associated with Experimental Hepatic Encephalopathy

   Author : Peter B F Bergqvist; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; serotonin; release; rat; quinolinic acid; potassium; chloroamphetamine; noradrenaline; neurotransmission; microdialysis; hepatic encephalopathy; fenfluramine; drug safety; dopamine; coma; citalopram; ammonia; calcium; brain; tryptophan; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Abstract : In the present study, L-tryptophan (TRP)-related disturbances in the brain in experimental hepatic encephalopathy (HE) were investigated. The endogenous NMDA-receptor agonist and L-TRP metabolite quinolinic acid (QUIN) has been suggested to be involved in the pathogenesis of HE. READ MORE

4. 2. Estrogen receptor gene activity within the brain and the relation to psychiatric disorders : mapping and function

   Author : Marie Österlund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : steroid hormone; ER system; in situ hybridization; rnRNA; ER serotonin; depression; affective disorders;

   Abstract : Estrogens have for a long time been known to regulate neuroendocrine functions in the central nervous system (CNS), primarily related to reproduction. In recent years estrogens have been found to also modulate many other brain functions, for example mood and cognition. READ MORE

5. 3. Metabolic signals in the regulation of insulin release

   Author : Jude T Deeney; Karolinska Institutet; Karolinska Institutet; []
   Keywords : insulin-secreting cells; glucose metabolism; ATP ADP ratio; cytoplasmic free Ca2 concentration; long-chain acyl-CoA; protein kinase C; insulin secretion; serotonin release; permeabilized cells; intracellular Ca2 handling; exocytosis;

   Abstract : In the present thesis, an attempt was made to elucidate the role of some of the glucose-induced intracellular metabolic effector signals in insulin secretion and to develop new applications that will enable further investigations of oscillatory signalling and secretion from pancreatic ß-cells. The sequence of early metabolic and ionic events was examined in clonal pancreatic insulin secreting cells (HIT) in response to glucose stimulation. READ MORE

6. 4. Towards Immunotherapy of Midgut Carcinoid Tumors

   Author : Sofia Vikman; Thomas Tötterman; Valeria Giandomenico; Bengt Widegren; Uppsala universitet; []
   Keywords : Immunology; midgut carcinoid; gene expression; immunotherapy; tumor antigen; VMAT-1; T cell; HLA-A*0201-binding peptide; IFNγ; regulatory T cell; Immunologi;

   Abstract : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. READ MORE