Search for dissertations about: "ERK1 2"
Showing result 1 - 5 of 103 swedish dissertations containing the words ERK1 2.
-
1. Unraveling Mechanisms of Insulin Resistance in Type 2 Diabetes in Human Adipocytes : Role of extracellular signal regulated kinase 1/2 (ERK1/2) and forkhead box protein 01 (FOX01)
Abstract : Type 2 Diabetes is characterized by hyperglycemia primarily caused due to insulin resistance in insulin responsive tissues and insufficient production of insulin by the β-cells. Insulin resistance appears to develop first in the expanding adipose tissue during caloric surplus and affects other tissues like liver and muscle by ectopic fat accumulation. READ MORE
-
2. Striatal adaptations in experimental parkinsonism and L-DOPA-induced dyskinesia
Abstract : Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by the loss of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc), resulting in typical motor symptoms. DA replacement with L-DOPA is the standard therapy for PD. READ MORE
-
3. Regulation and Function of MAP Kinases in PDGF Signaling
Abstract : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. READ MORE
-
4. Mechanisms of stretch-induced growth and contractile differentiation in vascular smooth muscle
Abstract : Vascular smooth muscle can adapt to increased intraluminal pressure by remodelling and hypertrophy, as seen in hypertension. The molecular mechanisms responsible for this are still incompletely characterized. READ MORE
-
5. The Role of Protein Kinase C in the Extracellular Ca2+-regulated Secretion of Parathyroid Hormone
Abstract : Parathyroid hormone (PTH) is the major physiological regulator of the extracellular Ca2+ concentration ([Ca2+]o) in the body. The secretion of this hormone is suppressed at high [Ca2+]o. READ MORE