Search for dissertations about: "ESI act"

Found 5 swedish dissertations containing the words ESI act.

  2. 1. Mass Spectrometry with Electrospray Ionization from an Adjustable Gap

    Author : Patrik Ek; Åsa Emmer; Johan Roeraade; Per M. Claesson; Ulrika Nilsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Electrospray ionization; mass spectrometry; nanoelectrospray; ESI; MS; chip; emitter; gap; liquid bridge; nozzle; peptides; Analytical chemistry; Analytisk kemi;

    Abstract : In this thesis the fabrication and analytical evaluation of two new electrospray emitters utilized for mass spectrometry analysis is presented. The emitters are based on a new concept, where the spray orifice can be varied in size. The thesis is based on two papers. All present-day nanoelectrospray emitters have fixed dimensions. READ MORE

  4. 2. Palladium(II)-Catalyzed Heck Reactions : Domino Reactions, Decarboxylations, Mechanistic Studies & Continuous Flow Applications

    Author : Ashkan Fardost; Mats Larhed; Patrick Guiry; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; palladium II ; dft; reaction mechanisms; esi-ms; heck; decarboxylation; microwave; continuous flow;

    Abstract : This thesis describes research efforts dedicated to the development of palladium(II)-catalyzed oxidative Heck and Heck/Suzuki domino reactions, and the applications of a new microwave heating technology, purpose-built for continuous flow in organic synthesis.Paper I describes the development of a ligand-modulated approach for attaching aryl groups to a chelating vinyl ether. READ MORE

  5. 3. Experimental studies of cluster ions containing water, ammonia, pyridine and bisulphate

    Author : Mauritz Johan Ryding; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; clusters; ions; water; ammonia; pyridine; bisulphate; cross sections; collision induced dissociation CID ; kinetic modelling; electrospray ionization ESI ; time-of-flight TOF ; mass spectrometry;

    Abstract : Molecular cluster ions are fascinating subjects of study. Bridging the size gap between molecules and bulk, they often display non-trivial size dependent behaviour and properties. READ MORE

  6. 4. Functional Proteome analysis of the molecular mechanism of (myo)fibroblast differentiation

    Author : Johan Malmström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fibroblast myofibroblast extracellular matrix asthma COPD PDGF TGF-beta heparan sulfate proteoglycans proteomics mass spectrometry MALDI ESI; Metabolism; Biochemistry; Biokemi; metabolism;

    Abstract : Tissue remodeling is observed in several physiological conditions such as embryogenesis, senescence, wound healing and pregnancy, as well as in several pathological conditions such as fibrosis and tumorgenesis. Fibroblasts play a key role in this tissue remodeling due to their capability of altering the turnover of the extracellular matrix. READ MORE

  7. 5. Aspects of Antisense and Antigene Chemistry of Oligonucleotides Tethered to Intercalators

    Author : Dimitri Ossipov; Jesper Wengel; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; oligonucleotides; intercalators; ruthenium complexes; RNase H cleavage; photocross-linkage; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

    Abstract : Synthetic and physicochemical studies on appropriately functionalized ODN-conjugates have been performed to evaluate their abilities to act as antisense agents against RNA or as intramolecular DNA cross-linking agents. Intercalating aromatic systems [phenazine (Pnz), dipyridophenazine (DPPZ)] and metallointercalators such as Ru2+(phen)2(DPPZ) and Ru2+(tpy)(DPPZ)L [where L = chemically or photochemically labile ligand, phen = phenanthroline, tpy = terpyridine], which are covalently tethered to the oligo-deoxynucleotides (ODNs), have been chosen for this purpose. READ MORE