Search for dissertations about: "EXT2"
Found 5 swedish dissertations containing the word EXT2.
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1. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis
Abstract : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. READ MORE
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2. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?
Abstract : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. READ MORE
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3. Localization of five human genes by clinical and molecular genetic methods
Abstract : Four of the research projects reported in this thesis start from the gene effects observed in clinical practice. Finding a disease causing gene is challenging, exciting and beneficial for the patient, the family and for the society. READ MORE
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4. EXT Proteins in Heparan Sulfate Biosynthesis
Abstract : Heparan sulfate (HS) is a long unbranched polysaccharide composed of alternating glucosamine and hexuronic (glucuronic or iduronic) acid residues. Modification by sulfate groups in various positions generates a highly heterogeneous molecule. READ MORE
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5. Array based genetic profiling of bone and soft tissue tumors
Abstract : In this thesis, genetic alterations in bone and soft tissue tumors have been investigated with the purpose of identifying regions of importance for tumor development, diagnosis and prognosis. This has primarily been performed by array comparative genomic hybridization analysis and gene expression profiling of cytogenetically analyzed tumors. READ MORE