Search for dissertations about: "Enzyme Inhibitors therapeutic use"

Showing result 1 - 5 of 7 swedish dissertations containing the words Enzyme Inhibitors therapeutic use.

  2. 1. Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

    Author : Karin Engen; Mats Larhed; Mikael Elofsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compound screening; insulin-regulated aminopeptidase; IRAP; inhibitors; cognitive disorders; spiro-oxindole; quinazolinone; imidazopyridine; medicinal chemistry; structure-activity relationship; microwave heating; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. READ MORE

  4. 2. Characterization of Diagnostic Tools and Potential Treatments for Alzheimer’s Disease : PET ligands and BACE1 inhibitors

    Author : Fredrik Jeppsson; Anna-Lena Ström; Kerstin Iverfeldt; Samuel Svensson; Martin Hallbeck; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer’s disease; Diagnostics; Treatment; PET ligand; BACE1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a very complex disorder and the most common form of dementia. The two pathological hallmarks of AD are extracellular amyloid-β (Aβ) plaques in cerebral cortex, and intraneuronal neurofibrillary tangles. READ MORE

  5. 3. Cystatin C functions in vitro and in vivo. Studies on target enzyme inhibition by cystatin C variants and cystatin C deficient mice

    Author : Katarina Håkansson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloidosis; E.coli expression; Cysteine proteases; protease inhibitors; Clinical chemistry; Klinisk kemi;

    Abstract : Cystatin C variants with Arg8, Leu9 and/or Val10 replaced by Gly residues were produced by site-directed mutagenesis and E. coli expression. READ MORE

  6. 4. Characterization of the PGE2 pathway in arthritis and inflammation : mPGES-1 as a therapeutic target

    Author : Patrick Leclerc; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inducible prostaglandin (PG) E2 pathway is defined by the concerted activities of the enzymes cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 in producing PGE2. PGE2 has pro-inflammatory and immunomodulatory functions and is involved in an array of diseases with an autoimmune and chronic inflammatory component, including rheumatoid arthritis (RA). READ MORE

  7. 5. Metabolic drug interactions in man : methodological aspects on in vivo studies

    Author : Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

    Abstract : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. READ MORE