Search for dissertations about: "Epidermal Growth Factor Receptor"

Showing result 11 - 15 of 133 swedish dissertations containing the words Epidermal Growth Factor Receptor.

  2. 11. Ubiquitination and Receptor Endocytosis

    Author : Kaisa Haglund; Carl-Henrik Heldin; Ivan Dikic; Harald Stenmark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Ubiquitination; receptor tyrosine kinase; endocytosis; Cbl; CIN85; EGFR; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Protein ubiquitination is an evolutionary conserved mechanism that controls a wide variety of cellular functions. Polyubiquitinated proteins are generally degraded in the proteasome, whereas monoubiquitination controls various other cellular processes, including endocytosis and endosomal sorting. READ MORE

  4. 12. Growth factors in spermatogenesis

    Author : Aida Wahlgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Testis; seminiferous tubules; proliferation; growth factors; sex steroids;

    Abstract : The aim of this study was to increase the knowledge of die effects of locally produced growth factors and hormones on germ cell proliferation in rat testis in vitro. Since impaired sperm production and function accounts for half the cases of infertility, it is important to understand the physiological actions in germ cell development. READ MORE

  5. 13. Cbl in Regulation of Growth Factor Receptor Endocytosis and Actin Dynamics

    Author : Iwona Szymkiewicz; Ivan Dikic; Silvia Giordano; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RTK; Cbl; endocytosis; ubiquitination; actin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. READ MORE

  6. 14. Transforming growth factor a in human hematopoietic cells

    Author : Thomas M. Walz; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : TGF-a, transforming growth factor a, is a potent growth factor belonging to the family of EGF (epidermal growth factor) -related proteins. Binding to the same receptor as EGF it has a ubiquitous repertoire of target cells, including, mesenchymal, epithelial and neuronal cells. READ MORE

  7. 15. Engineering Antibody Specificity Using Combinatorial Antibody Libraries

    Author : Jenny Boström; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; antibody Antigen Interactions; Dual Specific Antibodies; Herceptin; Human Epidermal Growth Factor Receptor 2; Thermodynamic Analysis; therapeutic Antibody Engineering; Synthetic Phagedisplayed Antibody Libraries; Vascular Endothelial Growth Factor; Bacterial Display; trastuzumab;

    Abstract : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. READ MORE