Search for dissertations about: "ErbB3"

Showing result 1 - 5 of 15 swedish dissertations containing the word ErbB3.

2. 1. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

   Author : Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Abstract : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. READ MORE

4. 2. Novel Roles of the Ack1 Kinase in Epithelial Biology

   Author : Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. READ MORE

5. 3. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications

   Author : Mikael Åstrand; Sophia Hober; John Löfblom; Larry Gold; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Protein G; ERBB2; ERBB3; Directed evolution; phage display; staphylococcal display; bispecific; Bioteknologi; Biotechnology;

   Abstract : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. READ MORE

6. 4. Functional analysis of Ipf1/Pdx1, MFng and Id during pancreatic growth and differentiation

   Author : Per Svensson; Helena Edlund; Henrik Semb; Umeå universitet; []
   Keywords : pancreas; proliferation; differentiation; signalling; expression; FgfR2IIIb; ErbB3; spondin1; MFng; Id; molekylär medicin genetik och patologi ; molecular medicine  genetics and pathology ;

   Abstract : The pancreas is an endodermally derived organ consisting of three major cell lineages. The endocrine cells, organised into the Islets of Langerhans, regulate blood glucose homeostasis by producing and secreting hormones such as glucagon and insulin into the bloodstream. READ MORE

7. 5. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

   Author : Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

   Abstract : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. READ MORE