Search for dissertations about: "Experimental models"

Showing result 1 - 5 of 2327 swedish dissertations containing the words Experimental models.

  2. 1. Experimental Evolution : and Fitness Effects of Mutations

    Author : Anna Knöppel; Dan I Andersson; Stanley Maloy; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Fitness effects; mutations; S20; fis; ribosome; horizontal gene transfer; adaptation; synonymous mutations; Mikrobiologi; Microbiology;

    Abstract : Bacteria have small, streamlined genomes and evolve rapidly. Their large population sizes allow selection to be the main driver of evolution. With advances in sequencing technologies and precise methods for genetic engineering, many bacteria are excellent models for studying elementary questions in evolutionary biology. READ MORE

  4. 2. Novel treatments of glioblastoma in experimental models

    Author : Karolina Förnvik; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Experimental glioma models; Glioblastoma; Complement system; C1 esterase inhibitor; ITPP; CRP; Glioma cells;

    Abstract : One of the major problems with malignant brain tumours, such as glioblastoma multiforme, is that despite being able to remove the major bulk of the tumour through surgery and treating the patients with chemotherapy and radiotherapy, we know that tumour cells have already spread throughout the brain. Furthermore, we now know that the glioblastoma cells effectively suppress the patients’ own anti-tumour response. READ MORE

  5. 3. On cyclic accumulation models for degradation of railway foundations

    Author : Hossein Tahershamsi; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Natural soft clay; Global Sensitivity Analysis; Sobol method; Experimental design; Rate-dependent models; Cyclic accumulation models; Cyclic degradation; Uncertainty analysis;

    Abstract : The degradation of railway foundations due to the repeated loading of traffic induces maintenance and safety obligations for the track operator. One major contributor to track degradation is the accelerated settlement rates in soft soils below the track that lead to alignment issues, especially at stiffness transitions. READ MORE

  6. 4. Experimental validation of dynamic component models

    Author : Per E. Blomberg; KTH; []
    Keywords : ;

    Abstract : Proper coil function is an important issue regardingair-handling devices. Thus, proper modeling is important. Thepresent work deals with simulation of heating coil subsystems,especially validation on component level. READ MORE

  7. 5. Experimental Chagas disease

    Author : John Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

    Abstract : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. READ MORE