Search for dissertations about: "FARMACI"

Showing result 1 - 5 of 629 swedish dissertations containing the word FARMACI.

  1. 1. In vitro and in silico prediction of drug-drug interactions with transport proteins

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Gustav Ahlin; Uppsala universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC transporter; OCT1; Organic cation transporter 1; SLC22A1; OATP1B1; SLCO1B1; Organic anion transporting peptide 1B1; Drug transport; Active transport; Genetic polymorphism; Cell lines; Gene expression; Multivariate data analysis; OPLS; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; PHARMACY Biopharmacy; FARMACI Biofarmaci; Pharmaceutics; galenisk farmaci; biofarmaci; Biopharmaceutics;

    Abstract : Drug transport across cells and cell membranes in the human body is crucial for the pharmacological effect of drugs. Active transport governed by transport proteins plays an important role in this process. A vast number of transport proteins with a wide tissue distribution have been identified during the last 15 years. READ MORE

  2. 2. Engineering of Pharmaceutical Particles Modulation of Particle Structural Properties, Solid-State Stability and Tabletting Behaviour by the Drying Process

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Jonas Berggren; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; particle engineering; microcrystalline cellulose pellets; intragranular porosity; convective drying; tabletting behaviour; spray-dried composite particles; amorphous lactose; PVP; heat and moisture-induced crystallisation; glass transition temperature; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Pharmaceutics; galenisk farmaci;

    Abstract : Relationships between stresses during the drying process, particle structural and functional properties, and particle engineering by the drying process were addressed in this thesis. In the first part, the importance of the drying phase and the effect of the drying rate on the intragranular porosity of microcrystalline cellulose pellets were investigated. READ MORE

  3. 3. New Concepts in Administration of Drugs in Tablet Form Formulation and Evaluation of a Sublingual Tablet for Rapid Absorption, and Presentation of an Individualised Dose Administration System

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Susanne Bredenberg; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Interactive mixture; Dose homogeneity; Disintegration; Bioadhesion; Oromucosal delivery; Sublingual tablet; Rapid absorption; Individual dosage; Drug dispensing device; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Pharmaceutics; galenisk farmaci;

    Abstract : This thesis presents two new concepts in oral drug administration and the results of evaluation of some relevant formulation factors.Investigation into improving the homogeneity of mixtures for tableting indicated that it may be possible to obtain interactive dry mixtures of micronised drugs containing drug proportions as low as 0.015% w/w. READ MORE

  4. 4. Mucosal Vaccination Using Polyacryl Starch Microparticles as Adjuvant with Salmonella enteritidis as a Model Pathogen

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Lena Strindelius; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; mucosal vaccination; polyacryl starch microparticles; salmonella enteritidis; flagellin; fimbriae; rCTB; LPS; Ussing chamber; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Pharmaceutics; galenisk farmaci;

    Abstract : Polyacryl starch microparticles have been developed as a new mucosal vaccine adjuvant intended for use in oral vaccination. The main objectives of this thesis were to evaluate the efficacy of these polyacryl starch microparticles and to study their uptake through mucosal tissues. READ MORE

  5. 5. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Staffan Tavelin; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Pharmaceutics; galenisk farmaci;

    Abstract : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. READ MORE