Search for dissertations about: "FGF-23"

Showing result 1 - 5 of 7 swedish dissertations containing the word FGF-23.

  1. 1. The Role of Fibroblast Growth Factor 23 in Phosphate Homeostasis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tobias Erik Martin Larsson; Uppsala universitet.; [2004]
    Keywords : Medical and Health Sciences Clinical Medicine Dermatology and Venereal Diseases; Medicin och hälsovetenskap Klinisk medicin Dermatologi och venereologi; Medicine; Fibroblast Growth Factor 23; FGF-23; phosphate homeostasis; vitamin D metabolism; sodium phosphate cotransporters; autosomal dominant hypophosphatemic rickets; ADHR; X-linked hypophosphatemic rickets; XLH; oncogenic osteomalacia; OOM; PHEX; Medicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Abstract : The regulation of serum phosphate (Pi) concentrations is a complex process and our current models are far from complete. Due to major advancements in biotechnology and the development of more powerful research tools, recent advances in the field of genetics has led to the identification of several candidates for the long sought-after phosphatonin(s), or Pi regulating hormones. READ MORE

  2. 2. Fibroblast growth factor-23 and Klotho in bone/mineral and parathyroid disorders

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Tijana Krajisnik; Uppsala universitet.; [2009]
    Keywords : Medical and Health Sciences Clinical Medicine Endocrinology and Diabetes; Medicin och hälsovetenskap Klinisk medicin Endokrinologi och diabetes; calcitriol; chronic kidney disease; CKD; chronic renal failure; fibroblast growth factor 23; fibroblast growth factor-23; FGF23; FGF-23; GalNac-T3; GALNT3; GFR; hyperostosis-hyperphosphatemia syndrome; HHS; Klotho; parathyroid hormone; PTH; hyperparathyroidism; pHPT; sHPT; uremic; vitamin D3; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Endocrinology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Endokrinologi; Internal Medicine; invärtesmedicin;

    Abstract : Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels of FGF23. READ MORE

  3. 3. FGF23 - a possible Phosphatonin

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Richard Marsell; Uppsala universitet.; [2008]
    Keywords : Surgery; Fibroblast growth factor 23; FGF23; FGF-23; Phosphate homeostasis; Vitamin D; Klotho; Parathyroid hormone; PTH; Kirurgi;

    Abstract : Human physiology is dependent on an accurate phosphate (Pi) homeostasis. Defective Pi regulation causes hyper- or hypophosphatemia, which are associated with ectopic calcification or impaired bone mineralization, and a shortened life span. Current endocrine models of Pi homeostasis are incomplete. READ MORE

  4. 4. The role of fibroblast growth factor-23 in chronic kidney disease-mineral and bone disorder

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Majd A. I. Mirza; Uppsala universitet.; [2010]
    Keywords : Medical and Health Sciences Clinical Medicine Urology and Nephrology; Medicin och hälsovetenskap Klinisk medicin Urologi och njurmedicin; Medical and Health Sciences Clinical Medicine Cardiac and Cardiovascular Systems; Medicin och hälsovetenskap Klinisk medicin Kardiologi; FGF23; FGF-23; CKD; CKD-MBD; cardiovascular disease; vascular function; atherosclerosis; hypertrophy; LVMI; LVH; fractures; bone; fat mass; obesity; apolipoproteins; cholesterol; lipids; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Kidney diseases; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Njursjukdomar; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Cardiovascular medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Kardiovaskulär medicin; Medicinsk vetenskap; Medical Science;

    Abstract : Fibroblast growth factor-23 (FGF23) was initially identified as the causative factor of autosomal dominant hypophosphatemic rickets. Further studies confirmed that FGF23 is predominantly expressed in the osteocytes and osteoblasts of bone and that circulating FGF23 acts on the kidney to inhibit renal phosphate reabsorption and 1,25(OH)2D3 hydroxylation. READ MORE

  5. 5. Studies on the phenotype and function of osteoclasts using osteopetrotic and rachitic animal models

    University dissertation from Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Author : Karin Hollberg; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone mineralization; bone resorption; osteoclast; tartrate-resistant acid phosphatase; proteolytic processing; cathepsin K; rickets; osteopetrosis; FGF-23;

    Abstract : Osteoclasts are multinucleated bone-resorbing cells that have been implicated in a variety of skeletal diseases e.g. osteoporosis, rheumatoid arthritis and skeletal metastasis. Under physiological conditions, the osteoclast participates in ossification during longitudinal bone growth as well as in bone remodelling during adulthood. READ MORE