Search for dissertations about: "FOXO3a"

Showing result 1 - 5 of 10 swedish dissertations containing the word FOXO3a.

  2. 1. Function of Innate Immune Cells in Breast Cancer

    Author : Fríða Björk Gunnarsdóttir; Malmö Cancerimmunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor associated macrophages; Breast cancer; Estrogen receptor alpha; FOXO3a; CD169; PD-L1; metastatic lymph node;

    Abstract : Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. READ MORE

  4. 2. Biological signature of HER2-positive breast cancer

    Author : Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Abstract : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. READ MORE

  5. 3. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development

    Author : Singareddy Rajareddy; Kui Liu; Anneli Stavreus-Evers; Umeå universitet; []
    Keywords : oocyte; follicular development; P13K pathway; medicinsk biokemi; Medical Biochemistry;

    Abstract : The intra-oocyte signaling pathways that control oocyte growth and early follicular development are largely unknown. The aim of this thesis was to investigate the regulation and functions of phosphatidylinositol 3 kinase (PI3K) pathway in the oocyte, focusing in the roles of Foxo3a, p27, and Pten (phosphatase and tensin homolog deleted on chromosome ten). READ MORE

  6. 4. The functional roles of the intra-oocyte phosphatidylinositol 3-kinase (PI3K) signaling in controlling follicular development in mice

    Author : Krishna Rao Jagarlamudi; Kui Liu; Lena Sahlin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oocyte; PI3K signaling; primordial follicle; Obstetrics and gynaecology; Obstetrik och gynekologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Abstract : The key functions of the mammalian ovary are the production of fertilizable oocytes and thesecretion of steroid hormones. At the time of birth the human ovary is composed of basic unitstermed primordial follicles. Primordial follicles are long-lived structures in the ovary and some ofthem last until the woman reaches menopause. READ MORE

  7. 5. Gender differences in chemical carcinogenesis

    Author : Sandeep Kadekar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Gender differences in cancer incidence and mortality is a regular finding in epidemiological studies. In addition to reproductive organs this pattern is also seen in non-reproductive organs, with men being the most affected gender for the majority of cancer-sites. READ MORE