Search for dissertations about: "Farmakologisk forskning"
Showing result 1 - 5 of 24 swedish dissertations containing the words Farmakologisk forskning.
-
1. Transcription Factor AP-2 in Relation to Personality and Antidepressant Drugs
Abstract : The CNS monoaminergic systems are considered as the head engine regulating neuropsychiatric functions and personality. Transcription factor AP-2 is known to be essential for the development of the brainstem including the monoaminergic nuclei, and has the ability to regulate many genes in the monoaminergic systems. READ MORE
-
2. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution
Abstract : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. READ MORE
-
3. Spontaneous reporting of adverse drug reactions : Possibilities and limitations
Abstract : Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy. They are a common cause of short-term hospitalization, prolonged hospitalization and death. Spontaneous reporting of ADRs remains one the most effective methods for detecting new and serious drug reactions. READ MORE
-
4. Transcription Factor AP-2 in Relation to Serotonergic Functions in the Central Nervous System
Abstract : Eukaryotic gene transcription plays a regulatory role in mammalian developmental processes. It has been shown that transcriptional control is an important mechanism for specification of neurotransmitter phenotypes. READ MORE
-
5. Preclinical Development of New Alkylating Oligopeptides for Cancer Therapy
Abstract : Oligopeptides can be used to carry cytotoxic agents in cancer chemotherapy, using tumour-associated proteins as the molecular target for selectivity. During the seventies and eighties Peptichemio, a cocktail of six alkylating oligopeptides carrying m-L-sarcolysin, was investigated in a wide variety of human malignancies. READ MORE