Search for dissertations about: "Fibrosis"

Showing result 1 - 5 of 311 swedish dissertations containing the word Fibrosis.

2. 1. Tomosynthesis in pulmonary cystic fibrosis

   Author : Kristina Vult von Steyern; Lund Diagnostisk radiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cystic fibrosis; Lung; Radiation dose; Radiography; Scoring methods; Tomography; spiral computed; X-ray computed;

   Abstract : The aims of this thesis were to investigate whether chest tomosynthesis might be used in pulmonary cystic fibrosis, to design and validate a tomosynthesis scoring system, and to determine the effective dose from chest tomosynthesis in children. In a prospective study starting in 2008 clinical chest radiography or computed tomography (CT) were supplemented with a tomosynthesis examination of the lungs. READ MORE

4. 2. Cellular and molecular mechanisms in immune mediated hepatic fibrosis. A study of the inflammatory syndrome and fibrosis development of the NIF mouse liver

   Author : Julia Nilsson; Autoimmunitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fibrosis; liver; mouse model; NKT cells; type 2 inflammation; inflammasome;

   Abstract : Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. READ MORE

5. 3. Towards Pharmacological Treatment of Cystic Fibrosis

   Author : Charlotte Andersson; Aleksander Edelman; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; cystic fibrosis; airway epithelium; genotype; CFTR; chloride transport; genistein; phenotype; phenylbutyrate; S-nitrosoglutathione; Cellbiologi; Cell biology; Cellbiologi; entomologi; Entomology;

   Abstract : S-nitrosogluthatione is an endogenous substance, present at decreased levels in the lungs of CF patients and was recently found to induce mature CFTR in airway epithelial CF cell lines. We show that S-nitrosoglutathione in physiological concentrations increases the presence of ΔF508 CFTR in the cell membrane and induces cAMP dependent chloride transport in cystic fibrosis airway epithelial cells. READ MORE

6. 4. Advances in Pharmacological Treatment of Cystic Fibrosis

   Author : Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
   Keywords : Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

   Abstract : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. READ MORE

7. 5. Macrophages in Crohn's Disease: lnnate immune cellular and molecular mechanisms driving intestinal inflammation and fibrosis

   Author : Frida Gorreja; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; macrophages; inflammatory macrophages; tissue-resident macrophages; efferocytosis; innate immunity; myeloid cells; fibroblasts; fibrosis; inflammasomes; Crohn´s disease; inflammatory bowel diseases; digestive diseases; mucosa immunology; intestinal immunity; intestinal inflammation; serum systemic inflammation; microbiota; metabolites;

   Abstract : Macrophages and their interactions with the lamina propria and luminal microenvi-ronment are crucial in the pathogenesis of Crohn´s disease (CD), a chronic inflamma-tory disease with a strong inflammatory innate immune involvement. Therefore, in-terpreting macrophage activity in the intestinal microenvironment may identify treatment targets beneficial for at least a subgroup of patients. READ MORE