Search for dissertations about: "Fitness compensation"

Showing result 1 - 5 of 11 swedish dissertations containing the words Fitness compensation.

  2. 1. Evolution of Antibiotic Resistance

    Author : Franziska Pietsch; Diarmaid Hughes; Josep Casadesús; Uppsala universitet; []
    Keywords : ciprofloxacin; rifampicin; bacterial fitness; compensation; mutation rate; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many important drugs needs to be met with the development of new antibiotics and alternative treatment options. READ MORE

  4. 2. Bacterial Resistance to Antimicrobial Peptides : Rates, Mechanisms and Fitness Effects

    Author : Maria Pränting; Dan Andersson; Ian Chopra; Uppsala universitet; []
    Keywords : antimicrobial peptides; antibiotic resistance; fitness cost; bacterial evolution; small colony variants; cyclotides; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Mikrobiologi; Microbiology;

    Abstract : The rapid emergence of bacterial resistance to antibiotics has necessitated the development of alternative treatment strategies. Antimicrobial peptides (AMPs) are important immune system components that kill microbes rapidly and have broad activity-spectra, making them promising leads for new pharmaceuticals. READ MORE

  5. 3. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Author : Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Keywords : Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Abstract : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. READ MORE

  6. 4. Mechanisms and Dynamics of Mecillinam Resistance in Escherichia coli

    Author : Elisabeth Thulin; Dan I Andersson; Laura Piddock; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mecillinam; Antibiotic resistance; Escherichia coli; Urinary tract infections; Fitness; Penicillin binding proteins; cysteine biosynthesis; Mikrobiologi; Microbiology;

    Abstract : The introduction of antibiotics in healthcare is one of the most important medical achievements with regard to reducing human morbidity and mortality. However, bacterial pathogens have acquired antibiotic resistance at an increasing rate, and due to a high prevalence of resistance to some antibiotics they can no longer be used therapeutically. READ MORE

  7. 5. Biotic and abiotic drivers of life-history and demographic variation in boreal orchids

    Author : Matthew R. Tye; Nina Sletvold; Yvonne Buckley; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Plant demography; life-history; climate; pollination; compensation; orchids; resources; Biology with specialization in Ecological Botany; Biologi med inriktning mot ekologisk botanik;

    Abstract : Environmental interactions, including both abiotic and biotic factors, are key drivers of life-history and population dynamics. Despite this, most population studies do not explicitly link variation in environmental factors and vital rates. READ MORE