Search for dissertations about: "Flavivirus"

Showing result 1 - 5 of 24 swedish dissertations containing the word Flavivirus.

  2. 1. The role of the type I interferons and viperin during neurotropic flavivirus infection

    Author : Richard Lindqvist; Anna Överby Wernstedt; Daniel Ruzek; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBEV; Flavivirus; Interferon; Neurotropic; Viperin;

    Abstract : Flaviviruses are globally distributed pathogens that cause millions of human infections annually. One of the most detrimental outcomes of flavivirus infection is encephalitis, which is caused by neurotropic flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), and Tick-borne encephalitis virus (TBEV). READ MORE

  4. 2. The Origin of the Genus Flavivirus and the Ecology of Tick-Borne Pathogens

    Author : John H.-O. Pettersson; Thomas Jaenson; Sven Bergström; Kenneth Nilsson; Mikael Thollesson; Per-Eric Lindgren; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Flavivirus; Virus dating; Molecular dating; Biogeography; Ixodes ricinus; Minimum infection rate; TBE; Tick-borne encephalitis virus; Rickettsia helvetica; Anaplasma phagocytophilum; Infection prevalence; RT-PCR; Biology with specialization in Systematics; Biologi med inriktning mot systematik;

    Abstract : The present thesis examines questions related to the temporal origin of the Flavivirus genus and the ecology of tick-borne pathogens. In the first study, we date the origin and divergence time of the Flavivirus genus. It has been argued that the first flaviviruses originated after the last glacial maximum. READ MORE

  5. 3. Host-pathogen interactions during tick-borne flavivirus infection : pathogenesis, tropism and tools

    Author : Ebba Rosendal; Anna K. Överby Wernstedt; Emma Nilsson; Jonathan D. Gilthorpe; Sonja M. Best; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tick-borne encephalitis virus; Langat virus; pathogenesis; type I interferons; central nervous system; neuroinflammation; structural proteins; Infectious Diseases; infektionssjukdomar; mikrobiologi; Microbiology;

    Abstract : Tick-borne encephalitis virus (TBEV) is a neurotropic member of the genus Flavivirus. It may transmit to humans through the bite of an infected tick or consumption of unpasteurized dairyproducts, and causes tick-borne encephalitis (TBE). TBE constitutes a significant health burden in Eurasia, with more than 10,000 cases reported every year. READ MORE

  6. 4. Functional characterization of interactions between the flavivirus NS5 protein and PDZ proteins of the mammalian host

    Author : Karin Ellencrona; Magnus Johansson; Andrew Davidson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tick-borne encephalitis virus TBEV ; West-Nile virus WNV ; Dengue virus DENV ; flavivirus; PDZ domains; ZO-2; ZO-1; RIMS2; Scribble; Interferon; JAK-STAT signaling; PDZ array; virus-host protein interaction; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Abstract : Flaviviruses are found all over the world and affect and infect millions of people every year. Flavivirus infection can lead to severe clinical outcomes resulting in neuronal damages e.g. Tick-borne encephalitis virus (TBEV), or severe hemorrhagic fevers e. READ MORE

  7. 5. Interplay between tick-borne encephalitis virus and the host innate immunity

    Author : Chaitanya Kurhade; Anna Överby Wernstedt; Nelson Gekara; Helen Lazear; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Virology; Flavivirus; IPS-1; Interferon; Viperin; mikrobiologi; Microbiology;

    Abstract : Flaviviruses are important emerging and re-emerging arthropod-borne pathogens that cause significant morbidity and mortality in humans. It consists of globally distributed human pathogens such as tick-borne encephalitis virus (TBEV), West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus (YFV), dengue virus (DENV), and Zika virus (ZIKV). READ MORE