Search for dissertations about: "Free drug concentration"
Showing result 1 - 5 of 49 swedish dissertations containing the words Free drug concentration.
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1. Intracellular unbound drug concentrations : Methodology and application for understanding cellular drug exposure
Abstract : Most known drug targets and metabolizing enzymes are located inside cells. Interactions with these proteins are determined by intracellular unbound drug concentrations. Assessing intracellular drug exposure is technically challenging, but essential for predicting pharmacokinetic, pharmacological, and toxicological profiles of new drugs. READ MORE
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2. Characterization of parameters influencing intracellular bioavailability and prediction of intracellular drug exposure
Abstract : This thesis work investigates factors influencing intracellular drug disposition. An experimental method for measurement of intracellular bioavailability (Fic), was used throughout. Fic is defined as the ratio between the unbound drug concentration inside the cell and the compound concentration in the cell exterior. READ MORE
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3. Towards specific quantification of exosomes using surface-based sensing
Abstract : When exosomes were first observed in 1967, they were believed to be cell debris until extensive studies demonstrated key biological functionalities related to their composition and formation mechanism. Exosomes are nanometer-sized lipid vesicles of endocytic origin, with a membrane consisting of lipids and proteins and encapsulating a cargo composed of soluble proteins and genetic material. READ MORE
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4. Miniaturized, Membrane-Based and Environmentally Green Sample Preparation Systems: Applications for Biological and Environmental Aqueous Samples
Abstract : Contemporary advancements in miniaturization of analytical systems have advantageously fostered development, automation, and hyphenation of a variety of sample preparation techniques. Among several downscaled extraction designs, porous synthetic polymeric membranes (such as flat sheet (FS) or hollow fiber (HF)) have been utilized for membrane-based extraction, separating two aqueous phases (as in supported liquid membrane (SLM) extraction or one aqueous phase and another organic phase (as in microporous membrane liquid-liquid extraction (MMLLE)). READ MORE
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5. Mass spectrometry based analysis of drugs, neurotransmitters and lipids in invertebrate model systems
Abstract : Mass spectrometry (MS) is one of the most universal analytical techniques due to its label-free detection principle and high chemical specificity, high selectivity, and sensitivity. MS is diverse with many different types of systems to meet different analytical demands from various research areas. READ MORE