Search for dissertations about: "G-protein"

Showing result 1 - 5 of 136 swedish dissertations containing the word G-protein.

  1. 1. Alpha-2 Adrenergic Receptors and Signal Transduction Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johnny Näsman; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; MEDICINE Physiology and pharmacology; MEDICIN Fysiologi och farmakologi; fysiologi; Physiology;

    Abstract : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. READ MORE

  2. 2. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Malin C Lagerström; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Classification; Structure; Pharmacology; Evolution; G protein-coupled receptor; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. READ MORE

  3. 3. Theoretical Studies of G-Protein-Coupled Receptors

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Xianqiang Sun; KTH.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biologisk fysik; Biological Physics;

    Abstract : The family of G-protein-coupled receptors (GPCRs) contains the largest number of drug targets in the human body, with more than a quarter of the clinically used drugs targeting them. Because of the important roles GPCRs play in the human body, the mechanisms of activation of GPCRs or ligands binding to GPCRs have captivated much research interest since the discovery of GPCRs. READ MORE

  4. 4. The Gene Repertoire of G protein-coupled Receptors New Genes, Phylogeny, and Evolution

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Þóra Kristín Bjarnadóttir; Uppsala universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. READ MORE

  5. 5. Evolution of the G protein-coupled receptor signaling system Genomic and phylogenetic analyses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Arunkumar Krishnan; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; GPCRs; G proteins; Sensory system; Signal transduction; Olfaction; Chemosensation; Hemichordates; Sponges; Porifera; Bilaterians; Holozoans; Fungi; Opisthokonts; Bioinformatik; Bioinformatics;

    Abstract : Signal transduction pathways mediated by G protein-coupled receptors (GPCRs) and their intracellular coupling partners, the heterotrimeric G proteins, are crucial for several physiological functions in eukaryotes, including humans. This thesis describes a broad genomic survey and extensive comparative phylogenetic analysis of GPCR and G protein families from a wide selection of eukaryotes. READ MORE