Search for dissertations about: "GH receptor"

Showing result 11 - 15 of 54 swedish dissertations containing the words GH receptor.

  2. 11. Targeting the GH/IGF-1 axis with novel, small molecule inhibitors

    Author : Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The growth hormone (GH) / insulin-like growth factor (IGF) family of ligands, binding proteins and receptors play multiple roles in cell growth, metabolism and development. In addition, numerous studies have demonstrated the pathophysiological importance of the GH/IGF-1 axis. READ MORE

  4. 12. GH Secretion in children. Methodological aspects of determining immunoreactive and bioactive isoforms

    Author : Chatarina Löfqvist; Göteborgs universitet; []
    Keywords : Growth hormone; immunoassay; cross-reactivity; standard; antibody; insulin-like growth factor 1; reference values;

    Abstract : A child's hormone-dependent growth is dependent on multiple factors, although linear growth is closely associated with levels of growth hormone (GH) secretion. As GH in serum exists in several isoforms, some of which may not be identified by immunoassay, possible alterations in the secretion of these different isoforms in childhood may influence growth and/or metabolism. READ MORE

  5. 13. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Author : Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. READ MORE

  6. 14. GH/IGF-I axis regulation of cardiovascular and neuronal gene expression and function

    Author : Anna Barlind; Göteborgs universitet; []
    Keywords : Growth hormone; rat; hypophysectomy; vascular resistance; gene expression; place learning; Intellicage; hexarelin; CNS; hippocampus; neurogenesis; cell survival; mouse;

    Abstract : Abstract Cardiovascular disease is a major cause of mortality in the Western world. Another important clinical condition is brain damage due to radiation therapy in cancer patients. This has neurological impairments presenting in the survivors. For both these conditions, it is important to develop new therapeutic strategies. READ MORE

  7. 15. Growth Hormone and Melanin-Concentrating Hormone receptor in the regulation of energy balance and metabolism

    Author : Mikael Bjursell; Göteborgs universitet; []
    Keywords : ;

    Abstract : Energy homeostasis ? the balance of energy intake, expenditure, and storage ? is controlled by autonomic regulation originating in the hypothalamus and the brain stem, which receive input from the periphery. Upon receiving signals from the periphery, centres in the central nervous system (CNS) react through endocrine or neuronal responses to maintain a steady balance. READ MORE