Search for dissertations about: "GL261"

Showing result 1 - 5 of 7 swedish dissertations containing the word GL261.

  2. 1. Molecular Regulation of Vascular Abnormalization and Its Role in Glioma

    Author : Lei Zhang; Anna Dimberg; Rolf Bjerkvig; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; vasculature; pleiotrophin; PTN; CD93; angiogenesis; GL261; RCAS;

    Abstract : Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. READ MORE

  4. 2. Immunological aspects of intratumoral chemotherapy and immunotherapy in malignant brain tumors

    Author : Julio Enriquez Perez; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma GBM ; Immunotherapy; Mouse glioma; Convection-enhanced delivery; Intratumoral chemotherapy; Glioblastom; Immuneterapi;

    Abstract : Advances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. READ MORE

  5. 3. Immunotherapy against malignant brain tumors - of mice and men

    Author : Karin Enell Smith; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor Immunology; Immunotherapy; Glioma; Mouse;

    Abstract : Glioblastoma Multiforme (GBM) is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance towards these treatments. READ MORE

  6. 4. Combined chemotherapy and immunotherapy against experimental malignant brain tumors

    Author : Sara Fritzell; Neurokirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cisplatin; Glioma; GM-CSF; IFN-gamma; IL-7; Immunotherapy; Intratumoral chemotherapy; Temozolomide;

    Abstract : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. Despite standard treatment including surgery, radiotherapy and temozolomide (TMZ)-based chemotherapy, the prognosis for GBM patients is dismal, and there is a need for novel treatments. READ MORE

  7. 5. Fibrosis in the central nervous system : the role of perivascular cells

    Author : Daniel Holl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regeneration in the adult mammalian central nervous system (CNS) is very limited. One limiting factor is the formation of chronic scar tissue, which inhibits axonal regeneration and functional recovery. READ MORE