Search for dissertations about: "GPR30"
Found 5 swedish dissertations containing the word GPR30.
-
1. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking
Abstract : The large protein family called G Protein-coupled receptors (GPCRs) has co-evolved with life throughout evolution; from single cell organisms all the way to complex beings such as us humans. The fact that GPCRs are involved in essentially every physiological event, and that ~50% of drugs on the current market are either directly or indirectly targeted towards the function of GPCRs, we can be certain of their considerable importance. READ MORE
-
2. The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis
Abstract : Cell migration is the first step of the invasive process, which is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. READ MORE
-
3. Identification and characterization of new mechanisms in cardiovascular estrogen signaling
Abstract : Women before menopause are protected from cardiovascular disease compared to age-matched men through mechanisms associated with the female sex hormone estrogen. There are three known estrogen receptors named ERα, ERβ and GPR30/GPER1, which are all three receptors are expressed in the cardiovascular system. READ MORE
-
4. Prevention of beta-cell dysfunction via targeting novel GPCRs in pancreatic islets
Abstract : The primary aim of this thesis was to investigate the role of G protein coupled receptors (GPCRs) in insulin secretion and beta-cell survival. The second aim was to determine which pathway is involved in insulin release and beta-cell protection via GPCRs. READ MORE
-
5. Modulation of hormone signaling by cadmium : from molecular mechanisms to health implications
Abstract : Cadmium is a toxic metal classified as human carcinogen and ubiquitously found in our environment mainly from anthropogenic activities. Exposure to cadmium has been associated with increased risk of certain hormone-dependent cancers in humans, and the metal has been proposed to possess endocrine disruptive properties by mimicking the physiological actions of estrogens. READ MORE