Search for dissertations about: "GSH transferase"

Showing result 1 - 5 of 20 swedish dissertations containing the words GSH transferase.

  2. 1. Purification and characterization of two GSH S-aryltransferases from rat liver : kinetic mechanism and error structure of kinetic data for GSH S-transferase A

    Author : Per Askelöf; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  4. 2. Effects of toxin-producing phytoplankton on copepods: feeding, reproduction and implications to the fate of toxins

    Author : Betina Kozlowsky-Suzuki; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ecology; Ekologi; GSH transferase; oocyte development; fate of toxins; toxin accumulation; toxic phytoplankton; copepods;

    Abstract : Phytoplankton growth and loss rates are governed by several factors and in many cases, when growth control fails, algal blooms are established. Such blooms can be formed by different phytoplankton species and some of them have harmful impacts on marine ecosystems. READ MORE

  5. 3. The Quest for Functional Quasi-Species in Glutathione Transferase Libraries

    Author : Arna Rúnarsdóttir; Bengt Mannervik; Ralf Morgenstern; Uppsala universitet; []
    Keywords : glutathione transferase; directed evolution; multivariate analysis; quasi-species; isothiocyanates; Biokemi; Biochemistry;

    Abstract : Glutathione transferases (GSTs) are good candidates for investigations of enzyme evolution, due to their broad substrate specificities and structural homology. The primary role of GSTs is to act as phase II detoxifying enzymes protecting the cell from toxic compounds of both endo- and exogenous origins. READ MORE

  6. 4. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering

    Author : Usama M. Hegazy; Bengt Mannervik; Mikael Widersten; T. J. Mantle; Uppsala universitet; []
    Keywords : Biochemistry; Glutathione transferase; targeted chemical modification; lock-and-key motif; cooperativity; stucture-function relationship; protein engineering; unnatural amino acid; site-specific mutation; Biokemi;

    Abstract : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. READ MORE

  7. 5. Studies on hepatic glutathione transferases from rat and man : 1. A kinetic mechanism for glutathione transferase A from rat liver. 2. Transferase µ, a new form of glutathione transferase in human liver

    Author : Margareta Warholm; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This study of glutathione transferases was undertaken to achieve a better understanding of the catalytic and molecular properties of various isozymes of this group of drug-metabolizing enzymes.The steady-state kinetics of purified glutathione transferase A from rat liver with glutathione (GSH) and 1,2-dichloro- 4-nitrobenzene as substrates, did not follow a simple Michaelis- Menten equation. READ MORE