Search for dissertations about: "GSK3"

Showing result 1 - 5 of 7 swedish dissertations containing the word GSK3.

2. 1. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

   Author : Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
   Keywords : Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

   Abstract : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. READ MORE

4. 2. Annotating and making use of the Avena sativa cv. Sang reference genome

   Author : Nikos Tsardakas Renhuldt; Tillämpad biokemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; oats; Avena sativa; genomics; genome annotation; gene mapping; mapping-by-sequencing; brassinosteroids; Fusarium; genetic markers; GFViz; GSK3; UGT; cereals; epicuticular wax; plant genomics; marker visualization; AsGSK2.1; AsCer-q;

   Abstract : Oats is an important cereal used for both food and feed. The topic of this thesis is the annotation of the genome of oat (Avena sativa) cv. Sang, as well as some of the things this genome and its annotation have been used for. READ MORE

5. 3. Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids

   Author : Olga Kotova; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Na ; K -ATPase; insulin; C-peptide; exercise; in vitro contraction; cardiotonic steroids; ouabain; marinobufagenin; ERK 1 2 MAP kinase; Src; p90 rsk; GSK3; signaling cascade; glycogen synthesis; human skeletal muscle cells; human renal tubular cells; rat skeletal muscle.;

   Abstract : Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. READ MORE

6. 4. Therapeutic myocardial angiogenesis and its pharmacological modulation

   Author : Anwar J Siddiqui; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Angiogenesis; arteriogenesis; ischemic heart; vascular endothelial growth factor; angiopoietin and receptor;

   Abstract : Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of combined angiogenic factors. READ MORE

7. 5. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1

   Author : Anita Popko-Scibor; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. READ MORE