Search for dissertations about: "GSTP1"
Showing result 1 - 5 of 16 swedish dissertations containing the word GSTP1.
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1. Pharmacogenetic analysis in sickness and in health - for better or for worse
Abstract : An individual's pharmacogenetic constitution may predict response to drugs, hormones and toxins, and might be a susceptibility factor for disease. Pharmacogenetic diversity is especially pronounced for drug metabolising enzymes. READ MORE
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2. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families
Abstract : Breast cancer is the most common cancer among Swedish women, affecting more than 7000 women each year. About 5-10% of all breast cancers are hereditary, with a monogenic inheritance pattern, but only 2-4% are explained by germline mutations in BRCA1 or BRCA2. BRCA1/BRCA2 mutation carriers have a 60-80% risk of developing breast cancer. READ MORE
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3. Carcinogenic polycyclic aromatic hydrocarbons : role of human glutathione transferases in conjugate formation and DNA protection
Abstract : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which requires metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bay- and fjord region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. READ MORE
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4. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering
Abstract : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. READ MORE
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5. Polyurethane - occupational exposure, biomarkers and symptoms
Abstract : Isocyanates may cause occupational asthma, rhinitis, and hypersensitivity pneumonitis. However, the mechanisms behind initiation of the disorders and the relations between exposure and effect are insufficiently elucidated. Means to biomonitor exposure and risk would be valuable. READ MORE