Search for dissertations about: "Galiellalactone"

Found 5 swedish dissertations containing the word Galiellalactone.

  2. 1. Galiellalactone Synthetic Studies

    Author : Zilma Escobar; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; natural product; galiellalactone; prostate cancer; STAT3.;

    Abstract : In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). READ MORE

  4. 2. GALIELLALACTONE ANALOGUES – SYNTHESIS AND PROPERTIES

    Author : Ritha Gidlöf; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galiellalactone; one-pot peptide coupling and intramolecular Michael addition; tandem palladium-catalyzed carbonylation intramolecular Diels-Alder; STAT3 inhibition;

    Abstract : Cancer cells use normal cell signalling pathways in a proliferative fashion in order to prolong their own survival. Inhibition of one of the major signal proteins, STAT3 (Signal Transducer and Activator of Transcription 3) has previously been shown to induce apoptosis. READ MORE

  5. 3. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Author : Martin H Johansson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Abstract : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. READ MORE

  6. 4. Studies of different secondary metabolites : Natural products from the mevalonate pathway

    Author : Mariela Alejandra Gonzales Ramirez; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Natural products; fungi; Galiellalactone; Galiella rufa; Trichilia adolfi; benzofuran;

    Abstract : Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment. READ MORE

  7. 5. STAT3 in Prostate Cancer

    Author : Nicholas Don-Doncow; Malmö Urologisk cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; STAT3; biomarker; Immunohistochemestry; Drug Resistance;

    Abstract : Prostate cancer is the second most common diagnosed cancer among men. Currently there are no reliablebiomarkers to distinguish between indolent and aggressive disease. When men progress to advanced stages of the disease treatment options are limited and resistance to treatments available today is a growing problem. READ MORE