Search for dissertations about: "Gastrointestinal stromal tumor GIST"

Showing result 1 - 5 of 11 swedish dissertations containing the words Gastrointestinal stromal tumor GIST.

2. 1. Gastrointestinal stromal tumors. Pathogenetic mechanisms, phenotypic characterization and prognosis

   Author : Johanna Andersson; Göteborgs universitet; []
   Keywords : Gastrointestinal stromal tumor GIST ; neurofibromatosis type I NF1 ; mutation; prognosis; denaturating high performance liquid chromatography dHPLC ; sequencing; KIT; PDGFRA; NF1;

   Abstract : Gastrointestinal stromal tumor (GIST), the most common non-epithelial neoplasm of the gastrointestinal tract, has historically been problematic both conceptually and clinically. Recently, GIST has been shown to share phenotypic features with the interstitial cells of Cajal (ICC), including the almost uniform expression of the tyrosine kinase receptor KIT. READ MORE

4. 2. Pancreatic Endocrine Tumors and GIST - Clinical Markers, Epidemiology and Treatment

   Author : Sara Ekeblad; Britt Skogseid; Peter Stålberg; Barbro Eriksson; Rajesh Thakker; Uppsala universitet; []
   Keywords : Medicine; Pancreatic endocrine tumor; Gastrointestinal stromal tumor; Neuroendocrine; Multiple endocrine neoplasia type 1; Prognostic factors; Temozolomide; TNM staging; O6-methylguanine DNA methyltransferase; Growth hormone secretagogue receptor; Ghrelin; Medicin;

   Abstract : Pancreatic endocrine tumors and gastrointestinal stromal tumors are rare. Evidence regarding prognostic factors, and in the former also treatment, is scarce. We evaluated the survival and prognostic factors in a consecutive series of 324 patients with pancreatic endocrine tumors treated at a single institution. READ MORE

5. 3. Molecular mechanisms of imatinib resistance in gastrointestinal stromal tumor with focus on microRNAs

   Author : Pınar Akçakaya; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Gastrointestinal stromal tumor (GIST) is mainly initialized by mutations in receptor tyrosine kinase genes KIT or PDGFRA. The development of imatinib, a small molecule inhibitor that targets these tyrosine kinase receptors, remarkably improved patient outcome. READ MORE

6. 4. Endosonography and pretreatment tumor profiling - from sampling, staining, to sequencing

   Author : Per Hedenström; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endosonography; fine-needle biopsy; pancreatic neoplasms; gastrointestinal stromal tumors; KIT; PDGFRA; Ki-67; imatinib; neoadjuvant therapy;

   Abstract : Background and aims: Endosonography-guided fine needle aspiration (EUS-FNA) is imperfect in diagnosing solid pancreatic lesions (SPL) and subepithelial lesions (SEL) including gastrointestinal stromal tumors (GIST). In GISTs, imatinib therapy is effective only in variants of oncogenes KIT and PDGFRA. READ MORE

7. 5. Novel aspects of the molecular biology of gastrointestinal stromal tumors

   Author : Erik Berglund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract (GI). Historically, these tumors were commonly mistaken for myogenic and neurogenic masses, and then eventually came to be recognized as a distinct type of soft-tissue sarcoma through ultrastructural findings and specific immunomarkers. READ MORE