Search for dissertations about: "Gene Dosage"
Showing result 1 - 5 of 65 swedish dissertations containing the words Gene Dosage.
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1. Avian Genome Evolution - Gene Expression, Gene Divergence and Sexual Dimorphism
Abstract : This study has focused on: (i) differences in how males and females use the genes in the genome, (ii) how sex chromosomes evolve and (iii) how the evolutionary rate of genes are affected by the chromosome on which they are located on and the gene expression level they experience. A large-scale microarray was developed for the zebra finch, Taeniopygia guttata and techniques were developed so that this microarray could also be used for wild passerine birds. READ MORE
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2. Adenovirus-mediated Gene Therapy of Prostate Cancer
Abstract : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. READ MORE
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3. Genomic adaptation and gene-dosage regulation of Drosophila melanogaster cells, and long-read software developments
Abstract : Cells are the vehicles that allows genetic code to proliferate in the world, taking on various forms – as illustrated by the tree of life. The cell features are determined by the manufacturing of proteins, a process that has its blueprints encoded as genes in the genome. READ MORE
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4. The Evolution of Sex Chromosomes and Dosage Compensation in Structurally Dynamic Butterfly Genomes
Abstract : Dimorphic sex chromosomes have evolved independently throughout evolution from initially homologous autosomes. Recombination suppression between the sex chromosomes causes one sex chromosome to degenerate, which will influence evolution of sex-linked genes. READ MORE
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5. Chromosome-wide gene regulatory mechanisms in Drosophila melanogaster
Abstract : In Drosophila there are two different chromosome-wide targeting systems, the dosage compensation system that equalizes the transcriptional output from X-linked genes between males and females, and the regulation of the 4th chromosome mediated by the POF protein. The best studied of these two mechanisms is the dosage compensation system. READ MORE