Search for dissertations about: "Global DNA Methylation"

Showing result 1 - 5 of 46 swedish dissertations containing the words Global DNA Methylation.

2. 1. Placental molecular mechanisms as pathways linking prenatal exposure to ambient air pollution to preeclampsia and fetal growth

   Author : Yumjirmaa Mandakh; Avdelningen för arbets- och miljömedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Preeclampsia; Ambient air pollution; placenta; Small-for-gestational age; mitochondrial DNA content; telomere length; global DNA methylation; gene expression; epigenetic age;

   Abstract : Background: Preeclampsia (PE) is a “multifactorial syndrome” in which ambient air pollution may contribute to the etiology of PE. However, the underlying mechanism of this association is not clearly elucidated. READ MORE

4. 2. Molecular Genetic and DNA Methylation Profiling of Chronic Lymphocytic Leukaemia : A Focus on Divergent Prognostic Subgroups and Subsets

   Author : Nicola Cahill; Richard Rosenquist; Larry Mansouri; Fergus Ryan; Denis Alexander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; Chronic lymphocytic leukemia; SNP; array; IGHV3-21; IGHV4-34; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Genetics; Genetik; Medical Genetics; Medicinsk genetik; Molecular Biology; Molekylärbiologi; Molekylär genetik; Molecular Genetics; Oncology; Onkologi;

   Abstract : Advancements in prognostication have improved the subdivision of chronic lymphocytic leukaemia (CLL) into diverse prognostic subgroups. In CLL, IGHV unmutated and IGHV3-21 genes are associated with a poor-prognosis, conversely, IGHV mutated genes with a favourable outcome. READ MORE

5. 3. DNA methylation in T cell leukaemia

   Author : Maike Bensberg; Colm Nestor; Maria Jenmalm; Sofie Degerman; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. READ MORE

6. 4. Aberrant DNA methylation in acute myeloid leukemia

   Author : Ying Qu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). READ MORE

7. 5. Genomic DNA methylation in health and disease

   Author : Mohsen Karimi Arzenani; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Cytosine methylation is one of the important epigenetic mechanisms controlling the vertebrate genome. Changes in genomic DNA methylation have been demonstrated in aging, auto-immune diseases and cancer. READ MORE