Search for dissertations about: "Goto-Kakizaki"

Showing result 1 - 5 of 31 swedish dissertations containing the word Goto-Kakizaki.

  2. 1. Protein and mRNA Studies of Rat FA1/Pref-1/dlk

    Author : Gabriella Persdotter Hedlund; Jann Hau; Carina Carlsson; Torgny Stigbrand; Uppsala universitet; []
    Keywords : Laboratory animals; Preadipocyte factor 1; delta like protein; Fetal antigen 1; Goto-Kakizaki; Zucker; adipokines; adipose tissue; diabetes; obesity; Försöksdjursvetenskap;

    Abstract : The timing of cell differentiation is important for development and renewal of well functioning organs and tissues. One protein involved in this process is Preadipocyte factor 1 (Pref-1). Most likely, the role of this protein is to maintain cells in an undifferentiated state. READ MORE

  4. 2. Dissecting the role of micro-RNAs in diabetes

    Author : Caroline Bolmeson; Create Health; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE

  5. 3. Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats

    Author : Jurgita Kundrotiené; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cortical compression; cerebral ischemia; neuroprotection; hyperglycemia; GotoKakizaki rats.;

    Abstract : Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes morphological changes and neurological deficits produced by mild to moderate brain ischemia and which can be used to identify novel, potentially useful, neuroprotective agents. READ MORE

  6. 4. Mechanisms of impaired insulin release in type-2 diabetes : studies in the GK rat model

    Author : Amel Guenifi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Goto-Kakizaki GK rat; Type-2 diabetes; insulin secretion; morphometry; adenylyl cyclase AC ; phospholipase-C PLC ; ß-cell;

    Abstract : Type-2 diabetes is a complex syndrome with a polygenic and multifactorial aetiology. It is characterised by its relatively late appearance in life and its mild progressive course. Glucose intolerance can generally be ascribed to disturbed pancreatic hormonal secretion and/or insulin resistance in the liver and extrahepatic tissues. READ MORE

  7. 5. Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats

    Author : Tiago J T Prazeres Moreira; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Focal ischemia; locomotor activity; lever-press task; neurodegeneration; hyperglycemia; Goto-Kakizaki rats; Fluoro-Jade; heme-oxygenase; astrocytes; microglia.;

    Abstract : Cerebrovascular disease and head trauma are among the leading causes of death and disability. In addition to severe motor disturbances, ischemia resulting from stroke or traumatic brain injury (TBI) can cause mild to severe cognitive deficits. READ MORE