Search for dissertations about: "HIV-1 protease"

Showing result 1 - 5 of 65 swedish dissertations containing the words HIV-1 protease.

  2. 1. Design and synthesis of HIV-1 protease inhibitors

    Author : Mathias Alterman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV-1; Protease; Inhibitors; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : Human Immunodeficiency Virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). The C2-symmetric HIV-1 protease is one of the prime targets for chemotherapy in the treatment of the HIV infection. Inhibition of HIV-1 protease leads to immature and non-infectious viral particles. READ MORE

  4. 2. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets : Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

    Author : Jimmy Lindberg; Torsten Unge; Alexander Wlodawer; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Abstract : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. READ MORE

  5. 3. Antiretroviral treatment of HIV-1 in the central nervous system

    Author : Aylin Yilmaz; Göteborgs universitet; []
    Keywords : HIV-1; cerebrospinal fluid; antiretroviral treatment; lopinavir; saquinavir; nelfinavir; neopterin; beta-2-microglobulin; HIV-1 RNA; IgG index; blood-brain barrier; albumin ratio; ultra-ultra sensitive PCR;

    Abstract : HIV-1 invades the central nervous system (CNS) early in the infectious course. It establishes a chronic progressive infection, and triggers an intrathecal immune response. If left untreated, a majority of patients will develop neurological complications, caused by opportunistic pathogens or HIV-1 itself. READ MORE

  6. 4. Cyclic Sulfamide HIV-1 Protease Inhibitors : Design, Synthesis and Modelling

    Author : Anna Ax; Anders Karlén; Anders Hallberg; Tommy Liljefors; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; AIDS; HIV; protease inhibitor; aspartic protease; molecular modelling; 3D-QSAR; CoMFA; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Abstract : Ten years ago, the first protease inhibitor targeting the human immunodeficiency virus (HIV) was approved for clinical use. Highly active antiretroviral therapy (HAART), which combined protease and reverse transcriptase inhibitors, quickly became the standard therapy for treating patients infected with HIV and Acquired Immune Deficiency Syndrome (AIDS). READ MORE

  7. 5. Structural Studies of Bacteriophage PRR1 and HIV-1 protease

    Author : Magnus Persson; Lars Liljas; Kaspars Tars; Félix Rey; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PRR1; HIV; Structural Biology; X-ray crystallography; PRR1; HIV-1 protease; NCS; crystallography; inhibitor; virus; bacteriophage; X-ray crystallography; Virology; Virologi; Molecular biology; Molekylärbiologi;

    Abstract : Viruses are a diverse genera of organisms adapted to thrive in many different hosts from prokaryotic to eukaryotic.We present here the structure of bacteriophage PRR1 virus-like particle (VLP), belonging to Leviviridae family. Our structure reveals calcium ions in the VLP. READ MORE