Search for dissertations about: "HLA-A2"

Showing result 1 - 5 of 20 swedish dissertations containing the word HLA-A2.

  2. 1. Analysis of HLA-A2 frequency as prognostic and/or risk factors in ovarian cancer patients

    Author : Zaynab Gamzatova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Major histocompatibility complex antigens are mandatory for the immune response, and genetic imbalance may be linked to tumour escape. The HLA-A2 allele in Scandinavia has a high prevalence; it decreases with latitude and also with ovarian cancer mortality in Europe. READ MORE

  4. 2. The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex

    Author : Jonas Söderholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; NS3; HLA-A2; viral fitness; DNA vaccine;

    Abstract : The hepatitis C virus (HCV) is a blood-borne virus responsible for a major part of liver transplants is the US, and 3% of the population world-wide is infected globally. HCV belongs to the Hepacivirus genus of the Flaviviridae family and is transmitted through infectious blood or blood products. READ MORE

  5. 3. Immunogenetic studies of multiple sclerosis

    Author : Arturs Ligers; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; CTLA-4; HLA-A2; HLA-A3; HLA-DRB1*15; HLA-DRB1*;

    Abstract : Multiple sclerosis (MS) is an inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Several genetic factors are likely to be of importance for MS rather than one factor. READ MORE

  6. 4. Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation

    Author : Flavio Salazar-Onfray; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The tumor antigens against which T cell responses have been demonstrated most frequently are not tumor specific but are also expressed on normal tissues. This observation has been interpreted as evidence for breaking of immunological tolerance to normal cellular proteins. READ MORE

  7. 5. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

    Author : Yang Rongcun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

    Abstract : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. READ MORE